Following dramatic success in many types of advanced solid tumors, interest in
immunotherapy for the treatment of colorectal cancer (CRC) is increasingly growing. Given …

Abstract cGMP controls many cellular functions ranging from growth, viability, and
differentiation to contractility, secretion, and ion transport. The mammalian genome encodes …

One major hurdle to the success of adoptive T-cell therapy is the identification of antigens
that permit effective targeting of tumors in the absence of toxicities to essential organs …

The enteric peptides, guanylin and uroguanylin, are local regulators of intestinal secretion
by activation of receptor-guanylate cyclase (R-GC) signaling molecules that produce cyclic …

Intestinal enteroendocrine cells are critical to central regulation of caloric consumption, since
they activate hypothalamic circuits that decrease appetite and thereby restrict meal size by …

Oncolytic viruses are natural or genetically modified viral species that selectively infect and
kill neoplastic cells. Such an innate or exogenously conferred specificity has generated …

Biomarkers are an integral part of cancer management due to their use in risk assessment,
screening, differential diagnosis, prognosis, prediction of response to treatment, and …

BACKGROUND Most cancer detection tests currently performed are based on either
antibody assays to a marker protein with altered expression in cancer patients or on imaging …

Nanotechnology has considerable promise for the detection, staging and treatment of
cancer. Here, we outline one such promising application: the use of nanostructures with …

Antitumor immunotherapy for colorectal cancer has been studied at the bench and bedside
for decades. Some clinical trials of cancer immunotherapy have demonstrated a potential …