In July 2022, these guidelines were reviewed by an expert work group convened by ASH.
Review included limited searches for new evidence and discussion of the search results …

While red blood cell (RBC) transfusion is the most common medical intervention in
hospitalized patients, as with any therapeutic, it is not without risk. Allogeneic RBC exposure …

Red blood cell (RBC) transfusions can result in alloimmunization toward RBC alloantigens
that can increase the probability of complications following subsequent transfusion. An …

Sickle cell disease (SCD) presents challenges to hematopoietic stem cell transplantation
(HSCT), including donor availability and morbidity with age/disease severity. However …

Red blood cell (RBC) transfusion is a critical component of optimal management for a broad
range of conditions. Regardless of the indication, pretransfusion testing is required to …

Chronic transfusion therapy (CTT) for sickle cell disease (SCD) reduces disease morbidity
by suppressing the amount of circulating hemoglobin S (HbS)‐containing red blood cells …

Red blood cell (RBC) alloimmunization represents a significant immunological challenge for
some patients. While a variety of immune constituents likely contribute to the initiation and …

Background Alloimmunization is a major problem in transfusion practice due to the clinical
complications of the patients and the difficulty of choosing a unit of compatible blood …

Background. Transfusion of red blood cells (RBC) is an essential therapeutic tool in sickle
cell disease (SCD). Repeated RBC transfusions can cause alloimmunization which causes …

One of the most important and persistent complications of blood transfusion is red blood cell
(RBC) alloimmunization. When a patient is exposed to RBC antigens that differ from their …