Minireview: role of orphan nuclear receptors in cancer and potential as drug targets

S Safe, UH Jin, E Hedrick, A Reeder… - Molecular …, 2014 - academic.oup.com
The nuclear orphan receptors for which endogenous ligands have not been identified
include nuclear receptor (NR) 0B1 (adrenal hypoplasia congenita critical region on …

Novel roles of gastrin

R Dimaline, A Varro - The Journal of physiology, 2014 - Wiley Online Library
The existence of the hormone gastrin in the distal stomach (antrum) has been known for
almost 110 years, and the physiological function of this amidated peptide in regulating …

HPV-induced Nurr1 promotes cancer aggressiveness, self-renewal, and radioresistance via ERK and AKT signaling in cervical cancer

PKT Wan, THY Leung, MKY Siu, XT Mo, HWM Tang… - Cancer Letters, 2021 - Elsevier
Human papillomavirus (HPV) is the etiological agent of cervical cancer; however, the
mechanisms underlying HPV-mediated carcinogenesis remain poorly understood. Here, we …

ZFP36L1 promotes gastric cancer progression via regulating JNK and p38 MAPK signaling pathways

K Ding, F Zhang, G Qi, M Lin, M Chen… - Recent Patents on …, 2023 - ingentaconnect.com
Background: The RNA-binding protein Zinc Finger Protein 36 like 1 (ZFP36L1) plays an
important role in regulating the AU-rich elements (AREs) in the 3′ untranslated region (3 …

Salt-inducible kinase 1 (SIK1) is induced by gastrin and inhibits migration of gastric adenocarcinoma cells

LKM Selvik, S Rao, TS Steigedal, I Haltbakk… - PLoS …, 2014 - journals.plos.org
Salt-inducible kinase 1 (SIK1/Snf1lk) belongs to the AMP-activated protein kinase (AMPK)
family of kinases, all of which play major roles in regulating metabolism and cell growth …

Role of Nurr1 in carcinogenesis and tumor immunology: a state of the art review

PKT Wan, MKY Siu, THY Leung, XT Mo, KKL Chan… - Cancers, 2020 - mdpi.com
Simple Summary Nuclear receptor related-1 protein (Nurr1) emerges as a therapeutic target
in multiple malignancies and immunotherapies. Previous studies have highlighted its …

Genome-wide miRNA response to anacardic acid in breast cancer cells

DJ Schultz, P Muluhngwi, N Alizadeh-Rad, MA Green… - PloS one, 2017 - journals.plos.org
MicroRNAs are biomarkers and potential therapeutic targets for breast cancer. Anacardic
acid (AnAc) is a dietary phenolic lipid that inhibits both MCF-7 estrogen receptor α (ERα) …

Bioactive dietary VDR ligands regulate genes encoding biomarkers of skin repair that are associated with risk for psoriasis

A Karrys, I Rady, RCN Chamcheu, MS Sabir, S Mallick… - Nutrients, 2018 - mdpi.com
Treatment with 1, 25-dihydroxyvitamin D3 (1, 25D) improves psoriasis symptoms, possibly
by inducing the expression of late cornified envelope (LCE) 3 genes involved in skin repair …

[HTML][HTML] LMX1B mRNA expression and its gene body CpG methylation are valuable prognostic biomarkers for laryngeal squamous cell carcinoma

L Fan, A Zhang, P Deng - Biomedicine & Pharmacotherapy, 2019 - Elsevier
This study aimed to explore the prognostic value of LMX1B mRNA expression and the
methylation of its CpG sites in patients with laryngeal squamous cell carcinoma (LSCC). An …

Circuits of cancer drivers revealed by convergent misregulation of transcription factor targets across tumor types

A Gonzalez-Perez - Genome medicine, 2016 - Springer
Background Large tumor genome sequencing projects have now uncovered a few hundred
genes involved in the onset of tumorigenesis, or drivers, in some two dozen malignancies …