Recombinant Chinese hamster ovary cells (rCHO) cells have been the most commonly used
mammalian host for large-scale commercial production of therapeutic proteins. Recent …

For over three decades, Chinese hamster ovary (CHO) cells have been the chosen
expression platform for the production of therapeutic proteins with complex post …

Normally, the growth profile of a CHO cell fed-batch process can be divided into two main
phases based on changes in cell concentration, being an exponential growth phase and a …

In recent years, monoclonal antibodies have emerged as an increasingly important class of
human therapeutics. A variety of forms of antibodies, including fragments such as Fabs …

Over the past 20 years, we have seen significant improvements in product titres from 50 mg/l
to 5–10 g/l, a more than 100‐fold increase. The main methods that have been employed to …

Methods to increase the production of recombinant proteins in mammalian cell cultures have
been developed which reduce in-culture growth through prohibiting progression of the cell …

Abstract Chinese Hamster Ovary cells are the primary system for the production of
recombinant proteins for therapeutic use. Protein productivity is directly proportional to …

Two CHO cell clones derived from the same parental CHO BC® cell line and producing the
same monoclonal antibody (BC-G, a low producing clone; BC-P, a high producing clone) …

To find a more effective chemical reagent for improved monoclonal antibody (mAb)
production, eight chemical reagents (curcumin, quercein, DL‐sulforaphane, thymidine …

Fed-batch culture of Chinese hamster ovary (CHO) cells remains the most commonly used
method for producing biopharmaceuticals. Static CHO cell-line engineering approaches …