Protein aggregation in biotherapeutics has been identified to increase immunogenicity,
leading to immune-mediated adverse effects, such as severe allergic responses including …

The efficacious detection of pathogens and prompt induction of innate immune signaling
serve as a crucial component of immune defense against infectious pathogens. Over the …

Severe forms of malaria are associated with systemic inflammation and host metabolism
disorders; however, the interplay between these outcomes is poorly understood. Using a …

Malaria reflects not only a state of immune activation, but also a state of general immune
defect or immunosuppression, of complex etiology that can last longer than the actual …

Kupffer cells (KCs) are self-maintained tissue-resident macrophages that line liver sinusoids
and play an important role on host defense. It has been demonstrated that upon infection or …

Epididymitis is an epididymal inflammation that may lead to male infertility. Dendritic cells
(DCs) and myeloid differentiation primary response gene 88 (Myd88) were associated with …

Introduction: Inflammatory processes play an important role in the pathophysiology of major
depressive disorder (MDD), but their relevance for specific symptoms such as …

Introduction: Acute respiratory distress syndrome (ARDS) remains a major clinical challenge
for patients in intensive care units. Determining the differential mechanisms underlying …

Cerebral malaria (CM) pathogenesis is described as a multistep mechanism. In this context,
monocytes have been implicated in CM pathogenesis by increasing the sequestration of …

Plasmodium berghei ANKA (PbA) infection in mice resembles several aspects of severe
malaria in humans, such as cerebral malaria and acute respiratory distress syndrome …