A uniform system for the annotation of vertebrate microRNA genes and the evolution of the human microRNAome
Although microRNAs (miRNAs) are among the most intensively studied molecules of the
past 20 years, determining what is and what is not a miRNA has not been straightforward …
past 20 years, determining what is and what is not a miRNA has not been straightforward …
Origins and diversification of animal innate immune responses against viral infections
Immune systems are of pivotal importance to any living organism on Earth, as they protect
the organism against deleterious effects of viral infections. Though the current knowledge …
the organism against deleterious effects of viral infections. Though the current knowledge …
The Amphimedon queenslandica genome and the evolution of animal complexity
M Srivastava, O Simakov, J Chapman, B Fahey… - Nature, 2010 - nature.com
Sponges are an ancient group of animals that diverged from other metazoans over 600
million years ago. Here we present the draft genome sequence of Amphimedon …
million years ago. Here we present the draft genome sequence of Amphimedon …
The evolutionary origin of plant and animal microRNAs
MicroRNAs (miRNAs) are a unique class of short endogenous RNAs, which have become
known in the past few decades as major players in gene regulation at the post …
known in the past few decades as major players in gene regulation at the post …
Evolution of RNA-and DNA-guided antivirus defense systems in prokaryotes and eukaryotes: common ancestry vs convergence
EV Koonin - Biology direct, 2017 - Springer
Complementarity between nucleic acid molecules is central to biological information transfer
processes. Apart from the basal processes of replication, transcription and translation …
processes. Apart from the basal processes of replication, transcription and translation …
Evolution of animal and plant dicers: early parallel duplications and recurrent adaptation of antiviral RNA binding in plants
K Mukherjee, H Campos… - Molecular biology and …, 2013 - academic.oup.com
RNA interference (RNAi) is a eukaryotic molecular system that serves two primary functions:
1) gene regulation and 2) protection against selfish elements such as viruses and …
1) gene regulation and 2) protection against selfish elements such as viruses and …
Metagenomic sequencing suggests a diversity of RNA interference-like responses to viruses across multicellular eukaryotes
RNA interference (RNAi)-related pathways target viruses and transposable element (TE)
transcripts in plants, fungi, and ecdysozoans (nematodes and arthropods), giving protection …
transcripts in plants, fungi, and ecdysozoans (nematodes and arthropods), giving protection …
DICER1‐associated embryonal rhabdomyosarcoma and adenosarcoma of the gynecologic tract: pathology, molecular genetics, and indications for molecular testing
M Apellaniz‐Ruiz, WG McCluggage… - Genes …, 2021 - Wiley Online Library
Gynecologic sarcomas are uncommon neoplasms, the majority occurring in the uterus. Due
to the diverse nature of these, the description of “new” morphological types and the rarity of …
to the diverse nature of these, the description of “new” morphological types and the rarity of …
Do miRNAs have a deep evolutionary history?
The recent discovery of microRNAs (miRNAs) in unicellular eukaryotes, including miRNAs
known previously only from animals or plants, implies that miRNAs have a deep …
known previously only from animals or plants, implies that miRNAs have a deep …
Untangling the roles of RNA helicases in antiviral innate immunity
M Baldaccini, S Pfeffer - PLoS Pathogens, 2021 - journals.plos.org
One of the first layers of protection that metazoans put in place to defend themselves against
viruses rely on the use of proteins containing DExD/H-box helicase domains. These …
viruses rely on the use of proteins containing DExD/H-box helicase domains. These …