Targeting mechanisms of tailed bacteriophages

FL Nobrega, M Vlot, PA De Jonge… - Nature Reviews …, 2018 - nature.com
Phages differ substantially in the bacterial hosts that they infect. Their host range is
determined by the specific structures that they use to target bacterial cells. Tailed phages …

Bacteriophage-based biosensors for detection of pathogenic microbes in wastewater

KB Shivaram, P Bhatt, MS Verma, K Clase… - Science of The Total …, 2023 - Elsevier
Wastewater is discarded from several sources, including industry, livestock, fertilizer
application, and municipal waste. If the disposed of wastewater has not been treated and …

Combination of pre-adapted bacteriophage therapy and antibiotics for treatment of fracture-related infection due to pandrug-resistant Klebsiella pneumoniae

A Eskenazi, C Lood, J Wubbolts, M Hites… - Nature …, 2022 - nature.com
A 30-year-old bombing victim with a fracture-related pandrug-resistant Klebsiella
pneumoniae infection after long-term (> 700 days) antibiotic therapy is treated with a pre …

Bacteria have numerous distinctive groups of phage–plasmids with conserved phage and variable plasmid gene repertoires

E Pfeifer, JA Moura de Sousa, M Touchon… - Nucleic acids …, 2021 - academic.oup.com
Plasmids and temperate phages are key contributors to bacterial evolution. They are usually
regarded as very distinct. However, some elements, termed phage–plasmids, are known to …

Isolation of phages for phage therapy: a comparison of spot tests and efficiency of plating analyses for determination of host range and efficacy

M Khan Mirzaei, AS Nilsson - PLoS one, 2015 - journals.plos.org
Phage therapy, treating bacterial infections with bacteriophages, could be a future
alternative to antibiotic treatment of bacterial infections. There are, however, several …

Phage–host interplay: examples from tailed phages and Gram-negative bacterial pathogens

S Chaturongakul, P Ounjai - Frontiers in microbiology, 2014 - frontiersin.org
Complex interactions between bacteriophages and their bacterial hosts play significant roles
in shaping the structure of environmental microbial communities, not only by genetic …

Effective inhibition of Salmonella Typhimurium in fresh produce by a phage cocktail targeting multiple host receptors

J Bai, B Jeon, S Ryu - Food Microbiology, 2019 - Elsevier
Salmonella contamination of fresh produce is the primary bacterial cause of a significant
number of foodborne outbreaks and infections. Bacteriophages can be used as natural …

Phage adsorption to gram-positive bacteria

A Leprince, J Mahillon - Viruses, 2023 - mdpi.com
The phage life cycle is a multi-stage process initiated by the recognition and attachment of
the virus to its bacterial host. This adsorption step depends on the specific interaction …

The evolutionary trade‐offs in phage‐resistant Klebsiella pneumoniae entail cross‐phage sensitization and loss of multidrug resistance

G Majkowska‐Skrobek, P Markwitz… - Environmental …, 2021 - Wiley Online Library
Bacteriophage therapy is currently being evaluated as a critical complement to traditional
antibiotic treatment. However, the emergence of phage resistance is perceived as a major …

Adsorption of bacteriophages on bacterial cells

AV Letarov, EE Kulikov - Biochemistry (Moscow), 2017 - Springer
The biological functions of bacteriophage virions come down to the solution of three basic
problems: to provide protection of viral nucleic acid from the factors of extracellular …