Risk factors and prevention of hepatocellular carcinoma in the era of precision medicine

N Fujiwara, SL Friedman, N Goossens, Y Hoshida - Journal of hepatology, 2018 - Elsevier
Patients who develop chronic fibrotic liver disease, caused by viral or metabolic aetiologies,
are at a high risk of developing hepatocellular carcinoma (HCC). Even after complete HCC …

[HTML][HTML] Advances in the early diagnosis of hepatocellular carcinoma

W Wang, C Wei - Genes & diseases, 2020 - Elsevier
Hepatocellular carcinoma (HCC) is one of the most prevalent cancers globally. In contrast to
the declining death rates observed for all other common cancers such as breast, lung, and …

Diagnosis, staging, and management of hepatocellular carcinoma: 2018 practice guidance by the American Association for the Study of Liver Diseases

JA Marrero, LM Kulik, CB Sirlin, AX Zhu, RS Finn… - Hepatology, 2018 - journals.lww.com
This guidance provides a data-supported approach to the diagnosis, staging, and treatment
of patients diagnosed with hepatocellular carcinoma (HCC). A guidance document is …

Osteopontin: a key regulator of tumor progression and immunomodulation

HR Moorman, D Poschel, JD Klement, C Lu, PS Redd… - Cancers, 2020 - mdpi.com
Simple Summary Anti-PD-1/PD-L1 and anti-CTLA-4-based immune checkpoint blockade
(ICB) immunotherapy have recently emerged as a breakthrough in human cancer treatment …

Novel biomarkers in hepatocellular carcinoma

F De Stefano, E Chacon, L Turcios, F Marti… - Digestive and Liver …, 2018 - Elsevier
Hepatocellular carcinoma (HCC) is the second leading cause of cancer-related deaths and
the fifth most common cancer worldwide. Most of these patients are seen with advanced …

Updating the clinical application of blood biomarkers and their algorithms in the diagnosis and surveillance of hepatocellular carcinoma: a critical review

E Shahini, G Pasculli, AG Solimando, C Tiribelli… - International Journal of …, 2023 - mdpi.com
The most common primary liver cancer is hepatocellular carcinoma (HCC), and its mortality
rate is increasing globally. The overall 5-year survival of patients with liver cancer is …

The role of cytokines in the different stages of hepatocellular carcinoma

N Rico Montanari, CM Anugwom, A Boonstra… - Cancers, 2021 - mdpi.com
Simple Summary Non-homeostatic cytokine expression during hepatocellular
carcinogenesis, together with simple and inexpensive cytokine detection techniques, has …

Cytokines and hepatocellular carcinoma: biomarkers of a deadly embrace

K Pocino, A Stefanile, V Basile, C Napodano… - Journal of Personalized …, 2022 - mdpi.com
Hepatocellular carcinoma (HCC) represents a worldwide health matter with a major care
burden, high prevalence, and poor prognosis. Its pathogenesis mainly varies depending on …

Both full-length and protease-cleaved products of osteopontin are elevated in infectious diseases

T Hattori, H Iwasaki-Hozumi, G Bai, H Chagan-Yasutan… - Biomedicines, 2021 - mdpi.com
Circulating full-length osteopontin (FL-OPN) is elevated in plasma from patients with various
infectious diseases, such as adult T-cell leukemia, Mycobacterium tuberculosis (TB) …

Liquid biopsy for early detection of hepatocellular carcinoma

I Manea, R Iacob, S Iacob, R Cerban, S Dima… - Frontiers in …, 2023 - frontiersin.org
Hepatocellular carcinoma (HCC) is a highly prevalent and lethal cancer globally. Over 90%
of HCC cases arise in the context of liver cirrhosis, and the severity of the underlying liver …