Macrophages play a central role in the development of atherosclerotic cardiovascular
disease (ASCVD), which encompasses coronary artery disease, peripheral artery disease …

Macrophages represent heterogeneous cell population with important roles in defence
mechanisms and in homoeostasis. Tissue macrophages from diverse anatomical locations …

Atherosclerotic Plaque Healing Atherosclerotic plaque rupture and erosion result in acute
coronary syndromes. Plaque healing after initial disruption has been less extensively …

Integrins are heterodimeric cell surface receptors ensuring the mechanical connection
between cells and the extracellular matrix. In addition to the anchorage of cells to the …

Initiation and progression of atherosclerosis depend on local inflammation and
accumulation of lipids in the vascular wall. Although many cells are involved in the …

Macrophage accumulation within the vascular wall is a hallmark of atherosclerosis. In
atherosclerotic lesions, macrophages respond to various environmental stimuli, such as …

With increasing age, the immune system undergoes a remodeling process, termed
immunosenescence, which is accompanied by considerable shifts in leukocyte …

The presence of macrophages within the plaque is a defining hallmark of atherosclerosis.
Macrophages are exposed to various microenvironments such as oxidized lipids and …

Living longer is associated with an increased risk of chronic diseases, including impairments
of the musculoskeletal and immune system as well as metabolic disorders and certain …

Background and purpose Studying the imaging and histopathologic characteristics of
thrombi in ischemic stroke could provide insights into stroke etiology and ideal treatment …