Urokinase-type plasminogen activator receptor (uPAR) is an attractive target for the
treatment of cancer, because it is expressed at low levels in healthy tissues but at high levels …

Cancer is not only composed malignant epithelial component but also stromal components
such as fibroblasts, endothelial cells, and inflammatory cells, by which an appropriate tumor …

Immunotargeting of tumor-specific antigens is a powerful therapeutic strategy.
Immunotherapies directed at MHC-I complexes have expanded the scope of antigens and …

Calcium-activated chloride channels (CaCCs) encoded by TMEM16A,, control neuronal
signalling, smooth muscle contraction, airway and exocrine gland secretion, and rhythmic …

In spite of its recent achievements, the technique of single particle electron cryomicroscopy
(cryoEM) has not been widely used to study proteins smaller than 100 kDa, although it is a …

Simple Summary Discovered more than three decades ago, the urokinase-type
plasminogen activator receptor (uPAR) has now firmly established itself as a versatile …

The diffuse-type gastric cancer (DGC) is a subtype of gastric cancer (GC) associated with
low HER2 positivity rate and insensitivity to chemotherapy and immune checkpoint …

Inorganic nanocrystals such as quantum dots (QDs) and upconverting nanoparticles
(UCNPs) are uniquely suited for quantitative live-cell imaging and are typically …

Components of the plasminogen activation system, which are overexpressed in aggressive
breast cancer subtypes, offer appealing targets for development of new diagnostics and …

Fibrinolysis is a crucial physiological process that helps to maintain a hemostatic balance by
counteracting excessive thrombosis. The components of the fibrinolytic system are well …