Undruggable proteins are a class of proteins that are often characterized by large, complex
structures or functions that are difficult to interfere with using conventional drug design …

Abstract Cyclooxygenase (COX) and Lipoxygenase (LOX) are essential enzymes for
arachidonic acid (AA) to eicosanoids conversion. These AA-derived eicosanoids are …

Introduction Recent years have seen significant strides in drug developmenttargeting the
EGFR/RAS/RAF signaling pathway which is critical forcell growth and proliferation. Protein …

For decades the direct targeting of KRAS as a driver of non‐small cell lung cancer,
colorectal and pancreatic cancers as well as the inhibition of the RAF‐MEK‐ERK pathway …

To valorise the bioactive constituents abundant in leaves and other parts of medicinal plants
with the objective to minimize the plant-based wastes, this study was undertaken. The main …

Two main objectives were pursued to assess the reliability of Thuja orientalis essential oils
(TOEO). The first objective was to extract TOEO, analyze them by GC‐MS, and determine …

Plasmodium species, which are spread by female Anopheles mosquitoes, are responsible
for malaria. Out of the five major Plasmodium species, Plasmodium falciparum and …

Neoantigens derived from somatic mutations in Kirsten Rat Sarcoma Viral Oncogene
Homolog (KRAS), the most frequently mutated oncogene, represent promising targets for …

Introduction The effect of the ethanol extracts of Curcuma longa Linn (yellow turmeric) and
Curcuma zedoaria Rosc (white turmeric) on cardiac oxidative stress in rats exposed to …

Muscle weakness as a secondary feature of attenuated neuronal input often leads to
disability and sometimes death in patients with neurogenic neuromuscular diseases. These …