Recent insights into the structure, function, and regulation of the eukaryotic transfer RNA splicing endonuclease complex
The splicing of transfer RNA (tRNA) introns is a critical step of tRNA maturation, for intron‐
containing tRNAs. In eukaryotes, tRNA splicing is a multi‐step process that relies on several …
containing tRNAs. In eukaryotes, tRNA splicing is a multi‐step process that relies on several …
Post-transcriptional control of cellular differentiation by the RNA exosome complex
I Fraga de Andrade, C Mehta… - Nucleic acids …, 2020 - academic.oup.com
Given the complexity of intracellular RNA ensembles and vast phenotypic remodeling
intrinsic to cellular differentiation, it is instructive to consider the role of RNA regulatory …
intrinsic to cellular differentiation, it is instructive to consider the role of RNA regulatory …
The Drosophila Nab2 RNA binding protein inhibits m6A methylation and male-specific splicing of Sex lethal transcript in female neuronal tissue
B Jalloh, CL Lancaster, JC Rounds, BE Brown… - Elife, 2023 - elifesciences.org
The Drosophila polyadenosine RNA binding protein Nab2, which is orthologous to a human
protein lost in a form of inherited intellectual disability, controls adult locomotion, axon …
protein lost in a form of inherited intellectual disability, controls adult locomotion, axon …
[HTML][HTML] Modeling pathogenic variants in the RNA exosome
J de Amorim, A Slavotinek, MB Fasken… - RNA & disease …, 2020 - ncbi.nlm.nih.gov
Exosomopathies are a collection of rare diseases caused by mutations in genes that encode
structural subunits of the RNA exosome complex (EXOSC). The RNA exosome is critical for …
structural subunits of the RNA exosome complex (EXOSC). The RNA exosome is critical for …
The putative RNA helicase DDX1 associates with the nuclear RNA exosome and modulates RNA/DNA hybrids (R-loops)
The RNA exosome is a ribonuclease complex that mediates both RNA processing and
degradation. This complex is evolutionarily conserved, ubiquitously expressed, and required …
degradation. This complex is evolutionarily conserved, ubiquitously expressed, and required …
A biallelic variant of the RNA exosome gene, EXOSC4, associated with neurodevelopmental defects impairs RNA exosome function and translation
The RNA exosome is an evolutionarily conserved complex required for both precise RNA
processing and decay. Pathogenic variants in EXOSC genes, which encode structural …
processing and decay. Pathogenic variants in EXOSC genes, which encode structural …
Vps54 Regulates Lifespan and Locomotor Behavior in Adult Drosophila melanogaster
EC Wilkinson, EL Starke, SA Barbee - Frontiers in genetics, 2021 - frontiersin.org
Vps54 is an integral subunit of the Golgi-associated retrograde protein (GARP) complex,
which is involved in tethering endosome-derived vesicles to the trans-Golgi network (TGN) …
which is involved in tethering endosome-derived vesicles to the trans-Golgi network (TGN) …
The Drosophila Nab2 RNA binding protein inhibits m6A methylation and male-specific splicing of Sex lethal transcript in female neuronal tissue
J Binta, CL Lancaster, RJ Christopher, BE Brown… - eLife, 2023 - search.proquest.com
The Drosophila polyadenosine RNA binding protein Nab2, which is orthologous to a human
protein lost in a form of inherited intellectual disability, controls adult locomotion, axon …
protein lost in a form of inherited intellectual disability, controls adult locomotion, axon …
The RNA-binding protein Nab2 regulates levels of the RhoGEF Trio to govern axon and dendrite morphology
CL Lancaster, PS Yalamanchili, JN Goldy… - Molecular Biology of …, 2024 - molbiolcell.org
The Drosophila RNA-binding protein (RBP) Nab2 acts in neurons to regulate
neurodevelopment and is orthologous to the human intellectual disability-linked RBP …
neurodevelopment and is orthologous to the human intellectual disability-linked RBP …
Mutations in Drosophila tRNA processing factors cause phenotypes similar to Pontocerebellar Hypoplasia
CA Schmidt, LY Min, MH McVay, JD Giusto… - Biology …, 2022 - journals.biologists.com
Mature transfer (t) RNAs are generated by multiple RNA processing events, which can
include the excision of intervening sequences. The tRNA splicing endonuclease (TSEN) …
include the excision of intervening sequences. The tRNA splicing endonuclease (TSEN) …