Biological and pharmacological aspects of the NK1‐receptor

S Garcia-Recio, P Gascón - BioMed research international, 2015 - Wiley Online Library
The neurokinin 1 receptor (NK‐1R) is the main receptor for the tachykinin family of peptides.
Substance P (SP) is the major mammalian ligand and the one with the highest affinity. SP is …

The emerging role of substance P/neurokinin-1 receptor signaling pathways in growth and development of tumor cells

H Javid, F Mohammadi, E Zahiri… - Journal of physiology and …, 2019 - Springer
Tachykinins (TKs) include an evolutionarily conserved group of small bio-active peptides
which possess a common carboxyl-terminal sequence, Phe-X-Gly-Leu-Met-NH2. TKs also …

Substance P autocrine signaling contributes to persistent HER2 activation that drives malignant progression and drug resistance in breast cancer

S Garcia-Recio, G Fuster, P Fernandez-Nogueira… - Cancer research, 2013 - AACR
ERBB receptor transmodulation by heterologous G-protein–coupled receptors (GPCR)
generates functional diversity in signal transduction. Tachykinins are neuropeptides and …

Neuropeptides in Cancer: Friend and Foe?

Y Wu, A Berisha, JC Borniger - Advanced Biology, 2022 - Wiley Online Library
Neuropeptides are small regulatory molecules found throughout the body, most notably in
the nervous, cardiovascular, and gastrointestinal systems. They serve as neurotransmitters …

Role of hemokinin-1 in health and disease

É Borbély, Z Helyes - Neuropeptides, 2017 - Elsevier
Abstract Hemokinin-1 (HK-1), the newest tachykinin encoded by the Tac4 gene was
discovered in 2000. Its name differs from that of the other members of this peptide family due …

Blood-forming stem cells are nervous: direct and indirect regulation of immature human CD34+ cells by the nervous system

A Kalinkovich, A Spiegel, S Shivtiel, O Kollet… - Brain, behavior, and …, 2009 - Elsevier
The nervous system regulates immunity through hormonal and neuronal routes as part of
host defense and repair mechanism. Here, we review the emerging evidence for regulation …

[HTML][HTML] 基于生物信息学分析老年骨质疏松差异表达基因及m6A相关蛋白的研究

周子墨, 陈佳慧, 陈森相, 覃森, 黄瑛, 柳达 - 中国医科大学学报, 2022 - html.rhhz.net
目的通过生物信息学方法探讨老年骨质疏松相关基因表达谱及m 6 A 相关蛋白基因表达.
方法检索GEO 数据库获得数据集, 使用R 语言软件分析获得差异表达基因(DEGs) …

[PDF][PDF] The role of the nervous system in hematopoietic stem cell mobilization

F Saba, M Soleimani, A Atashi, E Mortaz… - Lab Hematol, 2013 - academia.edu
Hematopoietic stem cells (HSCs) and blood cell progenitors, such as maturing leucocytes,
steadily enter from bone marrow (BM) into the circulation under steady-state conditions, and …

Neurokinin receptors as potential targets in breast cancer treatment

P Rameshwar, BY Reddy, KA Trzaska… - Current drug …, 2008 - ingentaconnect.com
Despite recent advances in the diagnoses and treatment of breast cancer, this disease
continues to be a major cause of death. One of the biggest challenges in breast cancer …

[图书][B] Osteoimmunopathology: evidence-based perspectives from molecular biology to systems biology

F Chiappelli - 2011 - books.google.com
Osteoimmunology pertains to the study of the relationship between the bones, particularly
the bone marrow, and the immune system. This monograph pursues the best available …