Worldwide, familial and epidemiological studies have generated considerable evidence of
an inherited component to prostate cancer. Indeed, rare highly penetrant genetic mutations …

Intra-tumor heterogeneity is one of the biggest challenges in cancer treatment today. Here
we investigate tissue-wide gene expression heterogeneity throughout a multifocal prostate …

CONTEXT: Despite widespread screening for prostate cancer (PCa) and major advances in
the treatment of metastatic disease, PCa remains the second most common cause of cancer …

Background The prostate-specific antigen (PSA) test is used to screen for prostate cancer
but has a high false-positive rate that translates into unnecessary prostate biopsies and …

Prostate cancer is a polygenic disease with a large heritable component. A number of
common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here …

Objective: We have previously identified peroxiredoxin-3 (PRDX-3) as a cell-surface protein
that is androgen regulated in the LNCaP prostate cancer (PCa) cell line. PRDX-3 is a …

Aurora kinases are serine/threonine kinases that play an essential role in cell division. Their
aberrant expression and/or function induce severe mitotic abnormalities, resulting in either …

BACKGROUND Prostate cancer is the most common cancer among men in the UK. Prostate-
specific antigen testing followed by biopsy leads to overdetection, overtreatment as well as …

Abstract N-acetyl-L-aspartyl-L-glutamate peptidase-like 2 (NAALADL2) is a member of the
glutamate carboxypeptidase II family, best characterized by prostate-specific membrane …

Single nucleotide polymorphisms (SNPs) have been classically used for dissecting various
human complex disorders using candidate gene studies. During the last decade, large scale …