The genetic epidemiology of prostate cancer and its clinical implications
R Eeles, C Goh, E Castro, E Bancroft, M Guy… - Nature reviews …, 2014 - nature.com
Worldwide, familial and epidemiological studies have generated considerable evidence of
an inherited component to prostate cancer. Indeed, rare highly penetrant genetic mutations …
an inherited component to prostate cancer. Indeed, rare highly penetrant genetic mutations …
Spatial maps of prostate cancer transcriptomes reveal an unexplored landscape of heterogeneity
Intra-tumor heterogeneity is one of the biggest challenges in cancer treatment today. Here
we investigate tissue-wide gene expression heterogeneity throughout a multifocal prostate …
we investigate tissue-wide gene expression heterogeneity throughout a multifocal prostate …
The role of genetic markers in the management of prostate cancer
CONTEXT: Despite widespread screening for prostate cancer (PCa) and major advances in
the treatment of metastatic disease, PCa remains the second most common cause of cancer …
the treatment of metastatic disease, PCa remains the second most common cause of cancer …
Prostate cancer screening in men aged 50–69 years (STHLM3): a prospective population-based diagnostic study
H Grönberg, J Adolfsson, M Aly, T Nordström… - The lancet …, 2015 - thelancet.com
Background The prostate-specific antigen (PSA) test is used to screen for prostate cancer
but has a high false-positive rate that translates into unnecessary prostate biopsies and …
but has a high false-positive rate that translates into unnecessary prostate biopsies and …
Fine-mapping of prostate cancer susceptibility loci in a large meta-analysis identifies candidate causal variants
T Dadaev, EJ Saunders, PJ Newcombe… - Nature …, 2018 - nature.com
Prostate cancer is a polygenic disease with a large heritable component. A number of
common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here …
common, low-penetrance prostate cancer risk loci have been identified through GWAS. Here …
Peroxiredoxin-3 is overexpressed in prostate cancer and promotes cancer cell survival by protecting cells from oxidative stress
Objective: We have previously identified peroxiredoxin-3 (PRDX-3) as a cell-surface protein
that is androgen regulated in the LNCaP prostate cancer (PCa) cell line. PRDX-3 is a …
that is androgen regulated in the LNCaP prostate cancer (PCa) cell line. PRDX-3 is a …
Leptin receptor maintains cancer stem-like properties in triple negative breast cancer cells
Q Zheng, L Banaszak, S Fracci, D Basali… - Endocrine-related …, 2013 - erc.bioscientifica.com
Aurora kinases are serine/threonine kinases that play an essential role in cell division. Their
aberrant expression and/or function induce severe mitotic abnormalities, resulting in either …
aberrant expression and/or function induce severe mitotic abnormalities, resulting in either …
[HTML][HTML] Active monitoring, radical prostatectomy and radical radiotherapy in PSA-detected clinically localised prostate cancer: the ProtecT three-arm RCT.
FC Hamdy, JL Donovan, JA Lane… - Health Technology …, 2020 - ncbi.nlm.nih.gov
BACKGROUND Prostate cancer is the most common cancer among men in the UK. Prostate-
specific antigen testing followed by biopsy leads to overdetection, overtreatment as well as …
specific antigen testing followed by biopsy leads to overdetection, overtreatment as well as …
N-acetyl-L-aspartyl-L-glutamate peptidase-like 2 is overexpressed in cancer and promotes a pro-migratory and pro-metastatic phenotype
Abstract N-acetyl-L-aspartyl-L-glutamate peptidase-like 2 (NAALADL2) is a member of the
glutamate carboxypeptidase II family, best characterized by prostate-specific membrane …
glutamate carboxypeptidase II family, best characterized by prostate-specific membrane …
Single nucleotide polymorphisms in clinics: Fantasy or reality for cancer?
S Srinivasan, JA Clements, J Batra - Critical reviews in clinical …, 2016 - Taylor & Francis
Single nucleotide polymorphisms (SNPs) have been classically used for dissecting various
human complex disorders using candidate gene studies. During the last decade, large scale …
human complex disorders using candidate gene studies. During the last decade, large scale …