Plant toxic proteins: their biological activities, mechanism of action and removal strategies

E Kocyigit, B Kocaadam-Bozkurt, O Bozkurt… - Toxins, 2023 - mdpi.com
Plants evolve to synthesize various natural metabolites to protect themselves against
threats, such as insects, predators, microorganisms, and environmental conditions (such as …

[HTML][HTML] Phylogeny and domain architecture of plant ribosome inactivating proteins

K Dougherty, KA Hudak - Phytochemistry, 2022 - Elsevier
Ribosome inactivating proteins (RIPs) are rRNA N-glycosylases (EC 3.2. 2.22) best known
for hydrolyzing an adenine base from the conserved sarcin/ricin loop of ribosomal RNA …

Ribosomal stalk-captured CARF-RelE ribonuclease inhibits translation following CRISPR signaling

I Mogila, G Tamulaitiene, K Keda, A Timinskas… - Science, 2023 - science.org
Prokaryotic type III CRISPR-Cas antiviral systems employ cyclic oligoadenylate (cAn)
signaling to activate a diverse range of auxiliary proteins that reinforce the CRISPR-Cas …

RNA-Seq Transcriptome Analysis Provides Candidate Genes for Resistance to Tomato Leaf Curl New Delhi Virus in Melon

C Sáez, A Flores-León, J Montero-Pau… - Frontiers in plant …, 2022 - frontiersin.org
Tomato leaf curl New Delhi virus (ToLCNDV) emerged in the Mediterranean Basin in 2012
as the first DNA bipartite begomovirus (Geminiviridae family), causing severe yield and …

Structural and functional characterization of the cytotoxic protein ledodin, an atypical ribosome‐inactivating protein from shiitake mushroom (Lentinula edodes)

L Citores, S Ragucci, R Russo, CC Gay… - Protein …, 2023 - Wiley Online Library
We have purified ledodin, a cytotoxic 22‐kDa protein from shiitake mushroom (Lentinula
edodes) consisting of a 197 amino acid chain. Ledodin possessed N‐glycosylase activity on …

The ribosome-inactivating proteins MAP30 and Momordin inhibit SARS-CoV-2

NR Watts, E Eren, I Palmer, PL Huang, PL Huang… - Plos One, 2023 - journals.plos.org
The continuing emergence of SARS-CoV-2 variants has highlighted the need to identify
additional points for viral inhibition. Ribosome inactivating proteins (RIPs), such as MAP30 …

[HTML][HTML] Isolation, characterization and biological action of type-1 ribosome-inactivating proteins from tissues of Salsola soda L.

N Landi, S Ragucci, L Citores, A Clemente… - Toxins, 2022 - mdpi.com
Ribosome-inactivating proteins (RIPs) are known as RNA N-glycosylases. They depurinate
the major rRNA, damaging ribosomes and inhibiting protein synthesis. Here, new single …

Death by ribosome

AC Vind, FL Zhong, S Bekker-Jensen - Trends in Cell Biology, 2024 - cell.com
Next to their essential role as protein production factories, ribosomes serve as molecular
sensors of cell stress. Stalled and collided ribosomes trigger specific stress signaling …

Structure and Biological Properties of Ribosome-Inactivating Proteins and Lectins from Elder (Sambucus nigra L.) Leaves

R Iglesias, R Russo, N Landi, M Valletta, A Chambery… - Toxins, 2022 - mdpi.com
Ribosome-inactivating proteins (RIPs) are a group of proteins with rRNA N-glycosylase
activity that catalyze the removal of a specific adenine located in the sarcin–ricin loop of the …

Deciphering Molecular Determinants Underlying Penicillium digitatum's Response to Biological and Chemical Antifungal Agents by Tandem Mass Tag (TMT)-Based …

L Citores, M Valletta, VP Singh, PV Pedone… - International Journal of …, 2022 - mdpi.com
Penicillium digitatum is a widespread pathogen responsible for the postharvest decay of
citrus, one of the most economically important crops worldwide. Currently, chemical …