Cellular metabolism orchestrates the intricate use of tissue fuels for catabolism and
anabolism to generate cellular energy and structural components. The emerging field of …

Osteoclasts are multinucleated cells with the unique ability to resorb bone matrix. Excessive
production or activation of osteoclasts leads to skeletal pathologies that affect a significant …

A growing body of research suggests that short-chain fatty acids (SCFAs), metabolites
produced by intestinal symbiotic bacteria that ferment dietary fibers (DFs), play a crucial role …

Microbial metabolites are known to modulate immune responses of the host. The main
metabolites derived from microbial fermentation of dietary fibers in the intestine, short-chain …

Osteoimmunity is involved in regulating the balance of bone remodeling and resorption, and
is essential for maintaining normal bone morphology. The interaction between immune cells …

Osteoblasts, the bone-forming cells of the remodeling unit, are essential for growth and
maintenance of the skeleton. Clinical disorders of substrate availability (eg, diabetes …

In recent decades, the mechanism underlying bone metabolic disorders based on energy
metabolism has been heavily researched. Bone resorption by osteoclasts plays an important …

Osteoclasts are multinucleated cells that are characterized by their unique ability to resorb
large quantities of bone. Therefore, they are frequently the target of therapeutic interventions …

Ferroptosis is an iron‐dependent cell death that has been found to aggravate the
progression of osteoarthritis (OA) and gut microbiota‐OA axis refers to the bidirectional …

Renewing interest in the study of intermediate metabolism and cellular bioenergetics is
brought on by the global increase in the prevalence of metabolic illnesses. Understanding of …