The role of Ca 2+ as a key and pivotal second messenger in cells depends largely on a wide
number of heterogeneous so-called calcium binding proteins (CBP), which have the ability …

Abstract Ca 2+ binding proteins (CBP) are of key importance for calcium to play its role as a
pivotal second messenger. CBP bind Ca 2+ in specific domains, contributing to the …

Calcineurin, a heterodimer composed of the catalytic (CnaA) and regulatory (CnaB)
subunits, plays key roles in growth, virulence and stress responses of fungi. To investigate …

The fungus Cryptococcus neoformans can undergo a-α bisexual and unisexual
reproduction. Completion of both sexual reproduction modes requires similar cellular …

Calcineurin (CaN) is a calcium-dependent phosphatase involved in numerous signaling
pathways. Its activation is in part driven by the binding of calmodulin (CaM) to a CaM …

Cav3. 2 T-type Ca2+ channel is required for the activation of calcineurin/NFAT signaling in
cardiac hypertrophy. We aimed to investigate how Cav3. 2 and calcineurin interact. We …

Lipid droplets (LD) are storage sites for neutral lipids that can be used as a source of energy
during nutrient starvation, but also function as hubs for fatty acid (FA) trafficking between …

Calcineurin (CN) is involved in many physiological processes and interacts with multiple
substrates. Most of the substrates contain similar motifs recognized by CN. Recent studies …

The type I diacylglycerol kinase (DGK) isozymes (α, β and γ) contain a shared recoverin
homology (RVH) domain, a tandem repeat of Ca2+-binding EF-hand motifs, two cysteine …

Diacylglycerol kinase (DGK) α, which is activated by Ca 2+, contains a recoverin homology
(RVH) domain, tandem repeats of two Ca 2+-binding EF-hand motifs, two cysteine-rich C1 …