“Frailty” is a term used to refer to a state characterized by enhanced vulnerability to, and
impaired recovery from, stressors compared with a nonfrail state, which is increasingly …

Chronic diseases are major killers in the modern era. Physical inactivity is a primary cause
of most chronic diseases. The initial third of the article considers: activity and prevention …

Hepatic steatosis is defined as intrahepatic fat of at least 5% of liver weight. Simple
accumulation of triacylglycerols in the liver could be hepatoprotective; however, prolonged …

Fatty liver accumulation results from an imbalance between lipid deposition and removal,
driven by the hepatic synthesis of triglycerides and de novo lipogenesis. The habitual diet …

Weight loss remains the most common therapy advocated for reducing hepatic lipid in
obesity and nonalcoholic fatty liver disease. Yet, reduction of body weight by lifestyle …

Nonalcoholic fatty liver disease (NAFLD) has been recognized as a major health burden.
The high prevalence of NAFLD is probably due to the contemporary epidemics of obesity …

Physical activity (PA) is commonly recommended for nonalchoholic fatty liver disease
(NAFLD) patients. However, there is limited evidence on the independent role of PA in …

Virtually all tissues in the human body rely on aerobic metabolism for energy production and
are therefore critically dependent on continuous supply of oxygen. Oxygen is provided by …

The majority of hepatocellular carcinoma occurs over pre-existing chronic liver diseases that
share cirrhosis as an endpoint. In the last decade, a strong association between lifestyle and …

Non-alcoholic fatty liver (NAFL) is the most common liver disorder in western society.
Various factors may play a role in determining hepatic fat content, such as delivery of lipids …