Targeting cellular senescence with senotherapeutics: senolytics and senomorphics
The concept of geroscience is that since ageing is the greatest risk factor for many diseases
and conditions, targeting the ageing process itself will have the greatest impact on human …
and conditions, targeting the ageing process itself will have the greatest impact on human …
Cellular senescence in ageing: from mechanisms to therapeutic opportunities
R Di Micco, V Krizhanovsky, D Baker… - … reviews Molecular cell …, 2021 - nature.com
Cellular senescence, first described in vitro in 1961, has become a focus for biotech
companies that target it to ameliorate a variety of human conditions. Eminently characterized …
companies that target it to ameliorate a variety of human conditions. Eminently characterized …
The flavonoid procyanidin C1 has senotherapeutic activity and increases lifespan in mice
Q Xu, Q Fu, Z Li, H Liu, Y Wang, X Lin, R He… - Nature …, 2021 - nature.com
Ageing-associated functional decline of organs and increased risk for age-related chronic
pathologies is driven in part by the accumulation of senescent cells, which develop the …
pathologies is driven in part by the accumulation of senescent cells, which develop the …
[HTML][HTML] Senolytics decrease senescent cells in humans: Preliminary report from a clinical trial of Dasatinib plus Quercetin in individuals with diabetic kidney disease
Background Senescent cells, which can release factors that cause inflammation and
dysfunction, the senescence-associated secretory phenotype (SASP), accumulate with …
dysfunction, the senescence-associated secretory phenotype (SASP), accumulate with …
From discoveries in ageing research to therapeutics for healthy ageing
For several decades, understanding ageing and the processes that limit lifespan have
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …
challenged biologists. Thirty years ago, the biology of ageing gained unprecedented …
Therapy-induced senescence: opportunities to improve anticancer therapy
PG Prasanna, DE Citrin, J Hildesheim… - JNCI: Journal of the …, 2021 - academic.oup.com
Cellular senescence is an essential tumor suppressive mechanism that prevents the
propagation of oncogenically activated, genetically unstable, and/or damaged cells …
propagation of oncogenically activated, genetically unstable, and/or damaged cells …
Senolytic drugs: reducing senescent cell viability to extend health span
Senescence is the consequence of a signaling mechanism activated in stressed cells to
prevent proliferation of cells with damage. Senescent cells (Sncs) often develop a …
prevent proliferation of cells with damage. Senescent cells (Sncs) often develop a …
Senolytics and senomorphics: Natural and synthetic therapeutics in the treatment of aging and chronic diseases
SM Lagoumtzi, N Chondrogianni - Free Radical Biology and Medicine, 2021 - Elsevier
Cellular senescence is a heterogeneous process guided by genetic, epigenetic and
environmental factors, characterizing many types of somatic cells. It has been suggested as …
environmental factors, characterizing many types of somatic cells. It has been suggested as …
Senescent cells: an emerging target for diseases of ageing
BG Childs, M Gluscevic, DJ Baker… - Nature reviews Drug …, 2017 - nature.com
Chronological age represents the single greatest risk factor for human disease. One
plausible explanation for this correlation is that mechanisms that drive ageing might also …
plausible explanation for this correlation is that mechanisms that drive ageing might also …
A senescence-centric view of aging: implications for longevity and disease
Cellular senescence is a state of stable cell cycle arrest associated with macromolecular
alterations and secretion of proinflammatory cytokines and molecules. From their initial …
alterations and secretion of proinflammatory cytokines and molecules. From their initial …