Alzheimer's disease (AD) is considered to have a large genetic component. Our knowledge
of this component has progressed over the last 10 years, thanks notably to the advent of …

Alzheimer's disease (AD) is a complex disorder with a clear genetic component. Three
genes have been identified as the cause of early onset familial AD (EOAD). The most …

Equivalence testing has grown significantly in importance over the last two decades,
especially as its relevance to a variety of applications has become understood. Yet …

The apolipoprotein E ε4 gene is the most important genetic risk factor for sporadic
Alzheimer's disease, but the link between this gene and neurodegeneration remains …

Alzheimer's disease (AD) is the most common type of dementia in the elderly population.
Three genes have been identified as responsible for the rare early-onset familial form of the …

Proteolytic processing of the β-amyloid precursor protein (APP) at the β site is essential to
generate Aβ. BACE1, the major β-secretase involved in cleaving APP, has been identified …

We previously have identified a large kindred from Colombia in which Alzheimer's disease
(AD) is caused by the E280A presenilin 1 (PS1) mutation. The objective of this study was to …

Genetic studies link inherited errors in RNA metabolism to familial neurodegenerative
disease. Here, we report such errors and the underlying mechanism in sporadic Alzheimer's …

Alzheimer's disease (AD) is the prime cause of dementia and presents a strong genetic
predisposition (60–80% of the attributable risk). In addition to APOE, a major recognized …

The ε4 allele of APOE confers a two-to fourfold increased risk for late-onset Alzheimer's
disease (LOAD), but LOAD pathology does not all fit neatly around APOE. It is conceivable …