Synthetic small molecule modulators of Hsp70 and Hsp40 chaperones as promising anticancer agents
B Nitzsche, M Höpfner, B Biersack - International Journal of Molecular …, 2023 - mdpi.com
A class of chaperones dubbed heat shock protein 70 (Hsp70) possesses high relevance in
cancer diseases due to its cooperative activity with the well-established anticancer target …
cancer diseases due to its cooperative activity with the well-established anticancer target …
The Plasmodium falciparum exported J domain proteins fine-tune human and malarial Hsp70s: pathological exploitation of proteostasis machinery
Cellular proteostasis requires a network of molecular chaperones and co-chaperones,
which facilitate the correct folding and assembly of other proteins, or the degradation of …
which facilitate the correct folding and assembly of other proteins, or the degradation of …
Cytokine-induced killer cells in combination with heat shock protein 90 inhibitors functioning via the Fas/FasL axis provides rationale for a potential clinical benefit in …
Constant efforts are being made to develop methods for improving cancer immunotherapy,
including cytokine-induced killer (CIK) cell therapy. Numerous heat shock protein (HSP) 90 …
including cytokine-induced killer (CIK) cell therapy. Numerous heat shock protein (HSP) 90 …
Impact of Histone Modifications and Their Therapeutic Targeting in Hematological Malignancies
M Markouli, D Strepkos, C Piperi - International journal of molecular …, 2022 - mdpi.com
Hematologic malignancies are a large and heterogeneous group of neoplasms
characterized by complex pathogenetic mechanisms. The abnormal regulation of epigenetic …
characterized by complex pathogenetic mechanisms. The abnormal regulation of epigenetic …
Orthogonal proteogenomic analysis identifies the druggable PA2G4-MYC axis in 3q26 AML
M Marchesini, A Gherli, E Simoncini, LMD Tor… - Nature …, 2024 - nature.com
The overexpression of the ecotropic viral integration site-1 gene (EVI1/MECOM) marks the
most lethal acute myeloid leukemia (AML) subgroup carrying chromosome 3q26 …
most lethal acute myeloid leukemia (AML) subgroup carrying chromosome 3q26 …
Histone modifications and their targeting in lymphoid malignancies
In a wide range of lymphoid neoplasms, the process of malignant transformation is
associated with somatic mutations in B cells that affect the epigenetic machinery …
associated with somatic mutations in B cells that affect the epigenetic machinery …
[HTML][HTML] Targeting MYC-driven lymphoma: lessons learned and future directions
S Martínez-Martín, ME Beaulieu… - Cancer Drug …, 2023 - ncbi.nlm.nih.gov
MYC plays a central role in tumorigenesis by orchestrating cell proliferation, growth and
survival, among other transformation mechanisms. In particular, MYC has often been …
survival, among other transformation mechanisms. In particular, MYC has often been …
Ricolinostat is not a highly selective HDAC6 inhibitor
G Médard, JM Sheltzer - Nature Cancer, 2023 - nature.com
A study in Nature Cancer by Zeleke et al. 1 described the results of a clinical trial using the
putative histone deacetylase (HDAC) 6 inhibitor ricolinostat. However, independent lines of …
putative histone deacetylase (HDAC) 6 inhibitor ricolinostat. However, independent lines of …
Defeating MYC with drug combinations or dual-targeting drugs
PE Thompson, J Shortt - Trends in Pharmacological Sciences, 2024 - cell.com
Members of the MYC family of proteins are a major target for cancer drug discovery, but the
development of drugs that block MYC-driven cancers has not yet been successful …
development of drugs that block MYC-driven cancers has not yet been successful …
Role of Rad18 in B cell activation and lymphomagenesis
K Kalweit, V Gölling, C Kosan, B Jungnickel - Scientific Reports, 2024 - nature.com
Maintenance of genome integrity is instrumental in preventing cancer. In addition to DNA
repair pathways that prevent damage to DNA, damage tolerance pathways allow for the …
repair pathways that prevent damage to DNA, damage tolerance pathways allow for the …