Tools for translation: non-viral materials for therapeutic mRNA delivery
KA Hajj, KA Whitehead - Nature Reviews Materials, 2017 - nature.com
In recent years, messenger RNA (mRNA) has come into the spotlight as a versatile
therapeutic with the potential to prevent and treat a staggering range of diseases. Billions of …
therapeutic with the potential to prevent and treat a staggering range of diseases. Billions of …
In vivo aspects of protein folding and quality control
BACKGROUND Proteins are synthesized on ribosomes as linear chains of amino acids and
must fold into unique three-dimensional structures to fulfill their biological functions. Protein …
must fold into unique three-dimensional structures to fulfill their biological functions. Protein …
Total synthesis of Escherichia coli with a recoded genome
Nature uses 64 codons to encode the synthesis of proteins from the genome, and chooses 1
sense codon—out of up to 6 synonyms—to encode each amino acid. Synonymous codon …
sense codon—out of up to 6 synonyms—to encode each amino acid. Synonymous codon …
mRNA structure regulates protein expression through changes in functional half-life
DM Mauger, BJ Cabral, V Presnyak… - Proceedings of the …, 2019 - National Acad Sciences
Messenger RNAs (mRNAs) encode information in both their primary sequence and their
higher order structure. The independent contributions of factors like codon usage and …
higher order structure. The independent contributions of factors like codon usage and …
Modifications of mRNA vaccine structural elements for improving mRNA stability and translation efficiency
Background mRNA vaccines hold great potential as therapeutic techniques against viral
infections due to their efficacy, safety, and large-scale production. mRNA vaccines offer …
infections due to their efficacy, safety, and large-scale production. mRNA vaccines offer …
[HTML][HTML] mRNA-based therapeutics—developing a new class of drugs
In vitro transcribed (IVT) mRNA has recently come into focus as a potential new drug class to
deliver genetic information. Such synthetic mRNA can be engineered to transiently express …
deliver genetic information. Such synthetic mRNA can be engineered to transiently express …
Codon bias as a means to fine-tune gene expression
The redundancy of the genetic code implies that most amino acids are encoded by multiple
synonymous codons. In all domains of life, a biased frequency of synonymous codons is …
synonymous codons. In all domains of life, a biased frequency of synonymous codons is …
Synonymous but not silent: the codon usage code for gene expression and protein folding
Codon usage bias, the preference for certain synonymous codons, is found in all genomes.
Although synonymous mutations were previously thought to be silent, a large body of …
Although synonymous mutations were previously thought to be silent, a large body of …
Codon usage influences the local rate of translation elongation to regulate co-translational protein folding
Codon usage bias is a universal feature of eukaryotic and prokaryotic genomes and has
been proposed to regulate translation efficiency, accuracy, and protein folding based on the …
been proposed to regulate translation efficiency, accuracy, and protein folding based on the …
[HTML][HTML] Single nucleotide polymorphisms and cancer susceptibility
NA Deng, H Zhou, H Fan, Y Yuan - Oncotarget, 2017 - ncbi.nlm.nih.gov
A large number of genes associated with various cancer types contain single nucleotide
polymorphisms (SNPs). SNPs are located in gene promoters, exons, introns as well as 5' …
polymorphisms (SNPs). SNPs are located in gene promoters, exons, introns as well as 5' …