The recent progress of isoxazole in medicinal chemistry
Isoxazole compounds exhibit a wide spectrum of targets and broad biological activities.
Developing compounds with heterocycle rings has been one of the trends. The integration of …
Developing compounds with heterocycle rings has been one of the trends. The integration of …
[HTML][HTML] The role of prostaglandins in different types of cancer
Á Jara-Gutiérrez, V Baladrón - Cells, 2021 - mdpi.com
The prostaglandins constitute a family of lipids of 20 carbon atoms that derive from
polyunsaturated fatty acids such as arachidonic acid. Traditionally, prostaglandins have …
polyunsaturated fatty acids such as arachidonic acid. Traditionally, prostaglandins have …
Recent advancement in the discovery and development of COX-2 inhibitors: Insight into biological activities and SAR studies (2008–2019)
Cyclooxygenase-2 is a very important physiological enzyme playing key roles in various
biological functions especially in the mechanism of pain and inflammation, among other …
biological functions especially in the mechanism of pain and inflammation, among other …
[HTML][HTML] Isoxazole derivatives as regulators of immune functions
M Zimecki, U Bąchor, M Mączyński - Molecules, 2018 - mdpi.com
In this review, we present reports on the immunoregulatory properties of isoxazole
derivatives classified into several categories, such as immunosuppressive, anti …
derivatives classified into several categories, such as immunosuppressive, anti …
Crocetin imparts antiproliferative activity via inhibiting STAT3 signaling in hepatocellular carcinoma
STAT3 is a key oncogenic transcription factor, often overactivated in several human cancers
including hepatocellular carcinoma (HCC). STAT3 modulates the expression of genes that …
including hepatocellular carcinoma (HCC). STAT3 modulates the expression of genes that …
Nonsteroidal anti‐inflammatory therapy: a journey toward safety
C Pereira‐Leite, C Nunes, SK Jamal… - Medicinal research …, 2017 - Wiley Online Library
The efficacy of nonsteroidal anti‐inflammatory drugs (NSAIDs) against inflammation, pain,
and fever has been supporting their worldwide use in the treatment of painful conditions and …
and fever has been supporting their worldwide use in the treatment of painful conditions and …
[HTML][HTML] Tris (dibenzylideneacetone) dipalladium (0)(Tris DBA) abrogates tumor progression in hepatocellular carcinoma and multiple myeloma preclinical models by …
L Arora, CD Mohan, MH Yang, S Rangappa… - Cancers, 2021 - mdpi.com
Simple Summary STAT3 is a major oncogenic transcription factor that is constitutively
activated in many types of human cancers, including hepatocellular carcinoma (HCC) and …
activated in many types of human cancers, including hepatocellular carcinoma (HCC) and …
[HTML][HTML] Brusatol, a Nrf2 inhibitor targets STAT3 signaling cascade in head and neck squamous cell carcinoma
STAT3 is a latent transcription factor that plays a vital role in the transmission of extracellular
signal from receptors to the nucleus. It has been regarded as a master transcription factor …
signal from receptors to the nucleus. It has been regarded as a master transcription factor …
Small molecule based five-membered heterocycles: A view of liquid crystalline properties beyond the biological applications
Liquid crystal (LC) is an intermediate phase of matter with the physical attributes of liquid,
and a high-level of orientational order of solids. This property of LCs has been widely …
and a high-level of orientational order of solids. This property of LCs has been widely …
Echinacoside induces mitochondria‐mediated pyroptosis through Raf/MEK/ERK signaling in non‐small cell lung cancer cells
Y Shi, H Cao, Z Liu, L Xi, C Dong - Journal of Immunology …, 2022 - Wiley Online Library
Background. Various natural compounds are effective in cancer prevention and treatment
with fewer side effects than conventional radiotherapy and chemotherapy. Considering the …
with fewer side effects than conventional radiotherapy and chemotherapy. Considering the …