In past decades, interdisciplinary research has been of great interest for scholars.
Thiazolidine motifs behave as a bridge between organic synthesis and medicinal chemistry …

Heterocyclic compounds play a tremendous role in the field of medicinal chemistry due to
their association with diverse pharmacological properties. Most of the pharmaceutical drugs …

Different compounds have been investigated as potent drugs for trypanosomiasis treatment,
but no new drug has been marketed in the past 3 decades. 4-Thiazolidinone/thiazole as …

The present work reports on the synthesis, anti-Trypanosoma cruzi activities and docking
studies of a novel series of 2-(pyridin-2-yl)-1, 3-thiazoles derived from 2-pyridine …

Chagas disease is one of the most significant health problems in the American continent.
benznidazole (BDZ) and nifurtimox (NFX) are the only drugs approved for treatment and …

A series of novel 4-thiazolidinone–pyrazoline conjugates have been synthesized and tested
for anti-Trypanosoma brucei activity. Screening data allowed us to identify five …

In this study, we designed and synthesized a series of thiophen-2-iminothiazolidine
derivatives from thiophen-2-thioureic with good anti-Trypanosoma cruzi activity. Several of …

Chagas disease is a deadly and centenary neglected disease that is recently surging as a
potential global threat. Approximately 30% of infected individuals develop chronic Chagas …

In previous studies, the compound 3-(bromopropiophenone) thiosemicarbazone was
described as a potent anti-Trypanosoma cruzi and cruzain inhibitor. In view to optimize this …

The discovery of new antiparasitic compounds against Trypanosoma cruzi, the etiological
agent of Chagas disease, is necessary. Novel aryloxy/aryl thiosemicarbazone-based …