Mesoporous silica nanoparticles in drug delivery and biomedical applications

Y Wang, Q Zhao, N Han, L Bai, J Li, J Liu, E Che… - … , Biology and Medicine, 2015 - Elsevier
In the past decade, mesoporous silica nanoparticles (MSNs) with a large surface area and
pore volume have attracted considerable attention for their application in drug delivery and …

[HTML][HTML] Silicon nitride as a biomedical material: an overview

X Du, SS Lee, G Blugan, SJ Ferguson - International Journal of Molecular …, 2022 - mdpi.com
Silicon nitride possesses a variety of excellent properties that can be specifically designed
and manufactured for different medical applications. On the one hand, silicon nitride is …

Dual actions of osteoclastic-inhibition and osteogenic-stimulation through strontium-releasing bioactive nanoscale cement imply biomaterial-enabled osteoporosis …

NH Lee, MS Kang, TH Kim, DS Yoon, N Mandakhbayar… - Biomaterials, 2021 - Elsevier
Repair of defective hard-tissues in osteoporotic patients faces significantly challenges with
limited therapeutic options. Although biomedical cements are considered promising …

The synergistic effects of Sr and Si bioactive ions on osteogenesis, osteoclastogenesis and angiogenesis for osteoporotic bone regeneration

L Mao, L Xia, J Chang, J Liu, L Jiang, C Wu, B Fang - Acta biomaterialia, 2017 - Elsevier
Bioactive ions released from bioceramics play important roles in bone regeneration;
however, it is unclear how each ionic composition in complex bioceramics exerts its specific …

Emerging nano-scale delivery systems for the treatment of osteoporosis

AP Dayanandan, WJ Cho, H Kang, AB Bello… - Biomaterials …, 2023 - spj.science.org
Osteoporosis is a pathological condition characterized by an accelerated bone resorption
rate, resulting in decreased bone density and increased susceptibility to fractures …

Copper-doped mesoporous silica nanospheres, a promising immunomodulatory agent for inducing osteogenesis

M Shi, Z Chen, S Farnaghi, T Friis, X Mao, Y Xiao… - Acta biomaterialia, 2016 - Elsevier
The application of mesoporous silica nanospheres (MSNs) loaded with drugs/growth factors
to induce osteogenic differentiation of stem cells has been trialed by a number of …

[HTML][HTML] Dye-doped silica nanoparticles: synthesis, surface chemistry and bioapplications

V Gubala, G Giovannini, F Kunc, MP Monopoli… - Cancer …, 2020 - Springer
Background Fluorescent silica nanoparticles have been extensively utilised in a broad
range of biological applications and are facilitated by their predictable, well-understood …

Europium-doped mesoporous silica nanosphere as an immune-modulating osteogenesis/angiogenesis agent

M Shi, L Xia, Z Chen, F Lv, H Zhu, F Wei, S Han… - Biomaterials, 2017 - Elsevier
Although much research has gone into the design of nanomaterials, inflammatory response
still impedes the capacity of nanomaterial-induced tissue regeneration. In-situ incorporation …

Nanoceria provides antioxidant and osteogenic properties to mesoporous silica nanoparticles for osteoporosis treatment

A Pinna, MT Baghbaderani, VV Hernández… - Acta biomaterialia, 2021 - Elsevier
Osteoporosis, a chronic metabolic bone disease, is the most common cause of fractures.
Drugs for treating osteoporosis generally inhibit osteoclast (OC) activity, but are rarely aimed …

Prospects and hazards of silica nanoparticles: Biological impacts and implicated mechanisms

R Ding, Y Li, Y Yu, Z Sun, J Duan - Biotechnology Advances, 2023 - Elsevier
With the thrive of nanotechnology, silica nanoparticles (SiNPs) have been extensively
adopted in the agriculture, food, cosmetic, and even biomedical industries. Due to the mass …