Acetylation is one of the major post-translational protein modifications in the cell, with
manifold effects on the protein level as well as on the metabolome level. The acetyl group …

Reversible protein acetylation is a major regulatory mechanism for controlling protein
function. Through genetic manipulations, dietary perturbations, and new proteomic …

It has long been recognized that energy metabolism is linked to the production of reactive
oxygen species (ROS) and critical enzymes allied to metabolic pathways can be affected by …

Abstract Sirtuin-3 (SIRT3) is a NAD+-dependent protein deacetylase that is located in
mitochondria, regulating mitochondrial proteins and maintaining cellular antioxidant status …

Mice deficient in the antioxidant enzyme Cu/Zn-superoxide dismutase (Sod1−/− or Sod1KO
mice) have increased oxidative stress, show accelerated aging and develop spontaneous …

Myocardial fuel and energy metabolic derangements contribute to the pathogenesis of heart
failure. Recent evidence implicates posttranslational mechanisms in the energy metabolic …

A growing number of studies have demonstrated the role of post-translational modifications
of proteins, particularly acetylation, in human diseases including neurodegenerative and …

There is an intimate interplay between cellular metabolism and the pathophysiology of
disease. Mitochondria are essential to maintaining and regulating metabolic function of cells …

Acetylation is one of the most important methods of modification that lead to a change in the
function of proteins. In humans, metabolic enzymes commonly undergo acetylation, which …

Metabolic dysregulation is a known hallmark of cancer progression, yet the oncogenic
signals that promote metabolic adaptations to drive metastatic cancer remain unclear. Here …