Ca2+ signaling is ubiquitous in eukaryotic cells and modulates many cellular events
including cell migration. Directional cell migration requires the polarization of both signaling …

Ras p21 protein activator 1 (RASA1) is a regulator of Ras GDP and GTP and is involved in
numerous physiological processes such as angiogenesis, cell proliferation, and apoptosis …

There is currently no effective treatment for pancreatic ductal adenocarcinoma (PDAC).
While palliative chemotherapy offers a survival benefit to most patients, nearly all will …

Considering cancer not only as malignant cells on their own but as a complex disease in
which tumor cells interact and communicate with their microenvironment has motivated the …

Calcium channel upregulation has been implicated in cancer cell proliferation and
progression including in breast cancer. Fortunately, the function of calcium channels can be …

The acidic pH of the tumor microenvironment plays a critical role in driving cancer
development toward a more aggressive phenotype, but the underlying mechanisms are …

Given that only a small percentage of human papillomavirus (HPV)-positive women develop
cancer, HPV is necessary but insufficient for carcinogenesis. Mucosally transmitted viral …

The aberrant expression of miRNA is strongly linked to numerous stages of triple‐negative
breast cancer (TNBC) progression, and it plays an indispensable role in the process from …

Voltage-gated calcium channels (VGCCs) and estrogen receptors are important cellular
proteins that have been shown to interact with each other across varied cells and tissues …

Ion channels, as functional molecules that regulate the flow of ions across cell membranes,
have emerged as a promising target in cancer therapy due to their pivotal roles in cell …