Significance: Metabolic syndrome is a frequent precursor of type 2 diabetes mellitus (T2D), a
disease that currently affects∼ 8% of the adult population worldwide. Pancreatic beta-cell …

During the past 30 yr, investigating the physiology of eating behaviors has generated a truly
vast literature. This is fueled in part by a dramatic increase in obesity and its comorbidities …

Cellular senescence is thought to contribute to age-associated deterioration of tissue
physiology. The senescence effector p16Ink4a is expressed in pancreatic beta cells during …

Hyperinsulinemia is associated with obesity and pancreatic islet hyperplasia, but whether
insulin causes these phenomena or is a compensatory response has remained unsettled for …

Pdx1 is a homeobox-containing transcription factor that plays a key role in pancreatic
development and adult β cell function. In this study, we traced the fate of adult β cells after …

Diabetes mellitus are complex, multi‐organ metabolic pathologies characterized by
hyperglycemia. Emerging evidence shows that the highly conserved and potent JAK/STAT …

Since its discovery over 100 years ago, insulin has been recognized as a key hormone in
control of glucose homeostasis. Deficiencies of insulin signaling are central to diabetes and …

Ductal cells have been proposed as a source of adult β cell neogenesis, but this has
remained controversial. By combining lineage tracing, 3D imaging, and single-cell RNA …

Recruitment and retention of leukocytes at a site of blood vessel growth are crucial for
proper angiogenesis and subsequent tissue perfusion. Although critical for many aspects of …

In November 1955, Geoffrey Harris published a paper based on the Christian A Herter
Lecture he had given earlier that year at Johns Hopkins University in Baltimore, MD, USA …