[HTML][HTML] Integrated multimodal cell atlas of Alzheimer's disease

MI Gabitto, KJ Travaglini, VM Rachleff… - Research …, 2023 - ncbi.nlm.nih.gov
Alzheimer's disease (AD) is the most common cause of dementia in older adults.
Neuropathological and imaging studies have demonstrated a progressive and stereotyped …

[HTML][HTML] Human midbrain dopaminergic neuronal differentiation markers predict cell therapy outcomes in a Parkinson's disease model

P Xu, H He, Q Gao, Y Zhou, Z Wu… - The Journal of …, 2022 - Am Soc Clin Investig
Human pluripotent stem cell–based (hPSC-based) replacement therapy holds great promise
for the treatment of Parkinson's disease (PD). However, the heterogeneity of hPSC-derived …

[HTML][HTML] Suppressing Retinal Remodeling to Mitigate Vision Loss in Photoreceptor Degenerative Disorders

RH Kramer - Annual Review of Vision Science, 2023 - annualreviews.org
Rod and cone photoreceptors degenerate in retinitis pigmentosa and age-related macular
degeneration, robbing the visual system of light-triggered signals necessary for sight …

Etiopathogenic models of psychosis spectrum illnesses must resolve four key features

S Vinogradov, AA Hamid, AD Redish - Biological psychiatry, 2022 - Elsevier
Etiopathogenic models for psychosis spectrum illnesses are converging on a number of key
processes, such as the influence of specific genes on the synthesis of proteins important in …

[HTML][HTML] HCN channels at the cell soma ensure the rapid electrical reactivity of fast-spiking interneurons in human neocortex

V Szegedi, E Bakos, S Furdan, BH Kovács… - PLoS …, 2023 - journals.plos.org
Accumulating evidence indicates that there are substantial species differences in the
properties of mammalian neurons, yet theories on circuit activity and information processing …

Postnatal development of electrophysiological and morphological properties in layer 2/3 and layer 5 pyramidal neurons in the mouse primary visual cortex

N Ciganok-Hückels, K Jehasse… - Cerebral …, 2023 - academic.oup.com
Eye-opening is a critical point for laminar maturation of pyramidal neurons (PNs) in primary
visual cortex. Knowing both the intrinsic properties and morphology of PNs from the visual …

[HTML][HTML] Alterations of the hippocampal networks in valproic acid-induced rat autism model

V Bódi, T Májer, V Kelemen, I Világi, A Szűcs… - Frontiers in neural …, 2022 - frontiersin.org
Autism Spectrum Disorder (ASD) is one of the most frequently diagnosed
neurodevelopmental disorders, characterized among others by impairments in social …

[HTML][HTML] PEX5R/Trip8b-HCN2 channel regulating neuroinflammation involved in perioperative neurocognitive disorders

F Xu, Y Wang, L Han, D Deng, Y Ding, LL Ma… - Cell & Bioscience, 2022 - Springer
Background Clinical and animal studies demonstrated that neuroinflammation from
anesthesia (sevoflurane) is the main contributor to cause perioperative neurocognitive …

The neuronal and synaptic dynamics underlying post-inhibitory rebound burst related to major depressive disorder in the lateral habenula neuron model

K Ma, H Gu, Y Jia - Cognitive Neurodynamics, 2024 - Springer
A burst behavior observed in the lateral habenula (LHb) neuron related to major depressive
disorder has attracted much attention. The burst is induced from silence by the excitatory N …

P2X7 receptors and pannexin1 hemichannels shape presynaptic transmission

N Vitureira, A Rafael, V Abudara - Purinergic Signalling, 2024 - Springer
Over the last decades, since the discovery of ATP as a transmitter, accumulating evidence
has been reported about the role of this nucleotide and purinergic receptors, in particular …