Biologists are increasingly recognising that computational modelling is crucial for making
sense of the vast quantities of complex experimental data that are now being collected. The …

In nonphotosynthetic organisms, mitochondria are the power plant of the cell, emphasizing
their great potentiality for adenosine triphosphate (ATP) synthesis from the redox span …

Given the vast behavioral repertoire and biological complexity of even the simplest
organisms, accurately predicting phenotypes in novel environments and unveiling their …

2. Topological Network Analysis 3. Stoichiometric Analysis 4. Intermediate Approaches B.
The Rationale of Mathematical Modeling III. The Basic Concepts of Metabolic Modeling A …

Background Mitochondria are a vital component of eukaryotic cells and their dysfunction is
implicated in a large number of metabolic, degenerative and age-related human diseases …

Mathematical models of mitochondrial bioenergetics provide powerful analytical tools to
help interpret experimental data and facilitate experimental design for elucidating the …

Cancer has been proposed as an example of systems biology disease or network disease.
Accordingly, tumor cells differ from their normal counterparts more in terms of intracellular …

Systems Biology holds that complex cellular functions are generated as system-level
properties endowed with robustness, each involving large networks of molecular …

Background The oxidation of fatty acids in mitochondria plays an important role in energy
metabolism and genetic disorders of this pathway may cause metabolic diseases. Enzyme …

Swelling of mitochondria plays an important role in the pathogenesis of human diseases by
stimulating mitochondria-mediated cell death through apoptosis, necrosis, and autophagy …