Candida albicans is a major fungal pathogen of humans. It exists as a commensal in the oral
cavity, gut or genital tract of most individuals, constrained by the local microbiota, epithelial …

Although new activation and regulatory mechanisms are still being identified, the basic
architecture of the complement system has been known for decades. Two major roles of …

Genetic susceptibility, the mucosal immune system, and environmental factors such as the
microbiota, stress, and diet, contribute to the pathogenesis of inflammatory bowel disease …

Complement is a complex protein network of plasma, and an integral part of the innate
immune system. Complement activation results in the rapid clearance of bacteria by immune …

The complement system is an essential player in innate and adaptive immunity. It consists of
three pathways (alternative, classical, and lectin) that initiate either spontaneously …

Denture-related Candida stomatitis, which has been described clinically in the literature, is
either localized or generalized inflammation of the oral mucosa in connection with a …

The innate immune response is evolutionary conserved among organisms. The complement
system forms an important and efficient immune defense mechanism. It consists of plasma …

The complement and coagulation systems are two related protein cascades in plasma that
serve important roles in host defense and hemostasis, respectively. Complement activation …

The diploid, polymorphic yeast Candida albicans is one of the most important human
pathogenic fungi. C. albicans can grow, proliferate and coexist as a commensal on or within …

Regulators of complement activation (RCA) inhibit complement‐induced immune responses
on healthy host tissues. We present crystal structures of human RCA (MCP, DAF, and CR 1) …