Capillary forces generated by biomolecular condensates

B Gouveia, Y Kim, JW Shaevitz, S Petry, HA Stone… - Nature, 2022 - nature.com
Liquid–liquid phase separation and related phase transitions have emerged as generic
mechanisms in living cells for the formation of membraneless compartments or biomolecular …

Physical principles underlying the complex biology of intracellular phase transitions

JM Choi, AS Holehouse… - Annual review of …, 2020 - annualreviews.org
Many biomolecular condensates appear to form via spontaneous or driven processes that
have the hallmarks of intracellular phase transitions. This suggests that a common …

Liquid phase condensation in cell physiology and disease

Y Shin, CP Brangwynne - Science, 2017 - science.org
BACKGROUND Living cells contain distinct subcompartments to facilitate spatiotemporal
regulation of biological reactions. In addition to canonical membrane-bound organelles such …

Screening membraneless organelle participants with machine-learning models that integrate multimodal features

Z Chen, C Hou, L Wang, C Yu, T Chen… - Proceedings of the …, 2022 - National Acad Sciences
Protein self-assembly is one of the formation mechanisms of biomolecular condensates.
However, most phase-separating systems (PS) demand multiple partners in biological …

Liquid-liquid phase separation in biology: mechanisms, physiological functions and human diseases

H Zhang, X Ji, P Li, C Liu, J Lou, Z Wang… - Science China Life …, 2020 - Springer
Cells are compartmentalized by numerous membrane-enclosed organelles and
membraneless compartments to ensure that a wide variety of cellular activities occur in a …

Autonomous materials systems from active liquid crystals

R Zhang, A Mozaffari, JJ de Pablo - Nature Reviews Materials, 2021 - nature.com
Liquid crystals (LCs) are ubiquitous in display technologies. The orientational ordering in the
nematic phase of LCs gives rise to structural anisotropy, the ability to form topological …

Supramolecular polymers form tactoids through liquid–liquid phase separation

H Fu, J Huang, JJB van der Tol, L Su, Y Wang, S Dey… - Nature, 2024 - nature.com
Liquid–liquid phase separation (LLPS) of biopolymers has recently been shown to play a
central role in the formation of membraneless organelles with a multitude of biological …

Mechanisms for active regulation of biomolecular condensates

J Söding, D Zwicker, S Sohrabi-Jahromi… - Trends in cell …, 2020 - cell.com
Liquid–liquid phase separation is a key organizational principle in eukaryotic cells, on par
with intracellular membranes. It allows cells to concentrate specific proteins into …

The actin cytoskeleton as an active adaptive material

S Banerjee, ML Gardel… - Annual review of …, 2020 - annualreviews.org
Actin is the main protein used by biological cells to adapt their structure and mechanics to
their needs. Cellular adaptation is made possible by molecular processes that strongly …

How it feels in a cell

M Bonucci, T Shu, LJ Holt - Trends in Cell Biology, 2023 - cell.com
Life emerges from thousands of biochemical processes occurring within a shared
intracellular environment. We have gained deep insights from in vitro reconstitution of …