Recent advances bioactive 1, 2, 4-triazole-3-thiones

ŞG Küçükgüzel, P Çıkla-Süzgün - European journal of medicinal chemistry, 2015 - Elsevier
Triazoles are heterocyclic compounds which have a five-membered ring of two carbon
atoms and three nitrogen atoms. These structures have been interest in the development of …

Thiadiazole—A promising structure in medicinal chemistry

Y Li, J Geng, Y Liu, S Yu, G Zhao - ChemMedChem, 2013 - Wiley Online Library
Many compounds containing a five‐membered heterocyclic ring display exceptional
chemical properties and versatile biological activities. In this Minireview, thiadiazoles are …

Synthesis, biological assay in vitro and molecular docking studies of new Schiff base derivatives as potential urease inhibitors

MAS Aslam, S Mahmood, M Shahid, A Saeed… - European Journal of …, 2011 - Elsevier
A series of new and novel Schiff base derivatives were synthesized and investigated as
potential new inhibitors of Jack bean urease. The most potent compounds were 3f with (Ki …

Urease inhibitors as potential drugs for gastric and urinary tract infections: a patent review

P Kosikowska, Ł Berlicki - Expert opinion on therapeutic patents, 2011 - Taylor & Francis
Introduction: Urease is the enzyme that catalyzes the hydrolysis of urea, which is involved in
serious infections caused by Helicobacter pylori in the gastric tract, as well as Proteus and …

[HTML][HTML] Anti-Helicobacter pylori and Urease Inhibition Activities of Some Traditional Medicinal Plants

M Amin, F Anwar, F Naz, T Mehmood, N Saari - Molecules, 2013 - mdpi.com
Different parts of Acacia nilotica (L.) Delile, Calotropis procera (Aiton) WT Aiton, Adhatoda
vasica Nees, Fagoniaar abica L. and Casuarina equisetifolia L. are traditionally used in folk …

Structural biology and drug discovery

G Scapin - Current pharmaceutical design, 2006 - ingentaconnect.com
In the past few years macromolecular crystallography has become a standard technique
used by many pharmaceutical and biotechnology companies. This methodology offers …

[HTML][HTML] Expression, Purification, and Comparative Inhibition of Helicobacter pylori Urease by Regio-Selectively Alkylated Benzimidazole 2-Thione Derivatives

SO Mohammed, ESH El Ashry, A Khalid, MR Amer… - Molecules, 2022 - mdpi.com
The urease enzyme has been an important target for the discovery of effective
pharmacological and agricultural products. Thirteen regio-selectively alkylated …

Syntheses, in vitro α-amylase and α-glucosidase dual inhibitory activities of 4-amino-1, 2, 4-triazole derivatives their molecular docking and kinetic studies

EO Yeye, KM Khan, S Chigurupati, A Wadood… - Bioorganic & medicinal …, 2020 - Elsevier
Abstract Thirty-three 4-amino-1, 2, 4-triazole derivatives 1–33 were synthesized by reacting
4-amino-1, 2, 4-triazole with a variety of benzaldehydes. The synthetic molecules were …

[HTML][HTML] The combined influences of exercise, diet and sleep on neuroplasticity

JW Pickersgill, CV Turco, K Ramdeo, RS Rehsi… - Frontiers in …, 2022 - frontiersin.org
Neuroplasticity refers to the brain's ability to undergo structural and functional adaptations in
response to experience, and this process is associated with learning, memory and …

[HTML][HTML] Green synthesis and characterization of silver nanoparticles through the Piper cubeba ethanolic extract and their enzyme inhibitory activities

K Ahmad, HM Asif, T Afzal, MA Khan, M Younus… - Frontiers in …, 2023 - frontiersin.org
The area of'Green Synthesis of Nano-medicine'as compared to synthetic counterparts is
relatively a safer research technology for various biomedical applications, including …