Liver cancer is a global health challenge, causing a significant social-economic burden.
Hepatocellular carcinoma (HCC) is the predominant type of primary liver cancer, which is …

Hypoxia is a known feature of solid tumors and a critical promoter of tumor hallmarks.
Hypoxia influences tumor immunity in a way favoring immune evasion and resistance …

Obesity-related complications such as non-alcoholic fatty liver disease (NAFLD) and type 2
diabetes (T2D) are well-established risk factors for the development of hepatocellular …

Background To investigate whether metformin monotherapy or adjunctive therapy improves
the prognosis in patients with any type of cancer compared to non-metformin users (age≥ …

Metformin and IACS‐010759 are two distinct antimetabolic agents. Metformin, an
established antidiabetic drug, mildly inhibits mitochondrial complex I, while IACS‐010759 is …

Introduction: Hepatocellular carcinoma (HCC) is the most common primary liver cancer and
the third cancer-related cause of death worldwide. In recent years, several systemic therapy …

Hepatocellular carcinoma (HCC) is insidious and prone to metastasis and recurrence.
Currently, no effective treatment is available for HCC. Furthermore, HCC does not respond …

Simple Summary This comprehensive review focuses on the role of epigenetics in oral
squamous cell carcinoma (OSCC), a prevalent type of oral cancer. The review highlights the …

This study examined the effect of combination treatment with the poly (ADP-ribose)
polymerase inhibitor olaparib and metformin on homologous recombination (HR)-proficient …

Oral cancer is one of the most common malignant tumors of the head and neck, not only
affects the appearance, but also affects eating and even endangers life. The clinical …