Many signal transductions resulting from ligand–receptor interactions occur at the cell
surface. These signaling pathways play essential roles in cell polarization, membrane …

Cell differentiation typically occurs with concomitant shape transitions to enable specialized
functions. To adopt a different shape, cells need to change the mechanical properties of their …

Contractile actomyosin bundles, stress fibers, govern key cellular processes including
migration, adhesion, and mechanosensing. Stress fibers are thus critical for developmental …

How local interactions of actin regulators yield large-scale organization of cell shape and
movement is not well understood. Here we investigate how the WAVE complex organizes …

Cells respond to both physical and chemical aspects of their substrate. Whether intracellular
signals initiated by physical stimuli are fundamentally different from those elicited by …

Many pathogens manipulate host cell cAMP signaling pathways to promote their survival
and proliferation. Bacterial Exoenzyme Y (ExoY) toxins belong to a family of invasive …

One challenge in cell biology is to decipher the biophysical mechanisms governing protein
enrichment on curved membranes and the resulting membrane deformation. The ERM …

Pulmonary endothelial barrier dysfunction is a hallmark of clinical pulmonary edema and
contributes to the development of acute lung injury (ALI). Here we reported that ruscogenin …

This study aimed to investigate the role and regulatory mechanisms of Ezrin in synovial
vessels in rheumatoid arthritis (RA). Synovial tissues were obtained from people with …

Animal cell shape changes are controlled by the actomyosin cortex, a peripheral actin
network tethered to the plasma membrane by membrane-to-cortex attachment (MCA) …