The role of oxidative stress in pathogenesis and treatment of inflammatory bowel diseases

A Piechota-Polanczyk, J Fichna - Naunyn-Schmiedeberg's archives of …, 2014 - Springer
In this review, we focus on the role of oxidative stress in the aetiology of inflammatory bowel
diseases (IBD) and colitis-associated colorectal cancer and discuss free radicals and free …

Oxidative stress and DNA damage: implications in inflammatory bowel disease

C Pereira, D Grácio, JP Teixeira… - Inflammatory bowel …, 2015 - academic.oup.com
This review will focus on published human studies on oxidative stress and DNA damage in
inflammatory bowel disease (IBD), both ulcerative colitis and Crohn's disease, assessing …

[PDF][PDF] Human catalase, its polymorphisms, regulation and changes of its activity in different diseases

J Kodydková, L Vávrová, M Kocík, A Zak - Folia biologica, 2014 - foliabiologica.lf1.cuni.cz
Catalase (CAT) is a well-studied enzyme that plays an important role in protecting cells
against the toxic effects of hydrogen peroxide. In human, it has been implicated in different …

[HTML][HTML] Genetic disorders coupled to ROS deficiency

S O'Neill, J Brault, MJ Stasia, UG Knaus - Redox biology, 2015 - Elsevier
Maintaining the redox balance between generation and elimination of reactive oxygen
species (ROS) is critical for health. Disturbances such as continuously elevated ROS levels …

The catalase C-262T gene polymorphism and cancer risk: a systematic review and meta-analysis

Y Shen, D Li, P Tian, K Shen, J Zhu, M Feng, C Wan… - Medicine, 2015 - journals.lww.com
Many studies suggest that catalase C-262T gene polymorphism is associated with cancer
risk, but with inconsistent results. This study aimed to summarize the overall association …

The genetic diversity and dysfunctionality of catalase associated with a worse outcome in Crohn's disease

M Iborra, I Moret, E Busó, JL García-Giménez… - International Journal of …, 2022 - mdpi.com
Chronic gut inflammation in Crohn's disease (CD) is associated with an increase in oxidative
stress and an imbalance of antioxidant enzymes. We have previously shown that catalase …

Microalgae as a Nutraceutical Tool to Antagonize the Impairment of Redox Status Induced by SNPs: Implications on Insulin Resistance

M Melloni, D Sergi, C Simioni, A Passaro, LM Neri - Biology, 2023 - mdpi.com
Simple Summary Oxidative stress is recognized as one of the pathogenetic mechanisms
underpinning insulin resistance, the hallmark of type 2 diabetes. Although oxidative stress …

The role of CYBA (p22phox) and catalase genetic polymorphisms and their possible epistatic interaction in cervical cancer

SA Castaldo, AP Da Silva, A Matos, Â Inácio, M Bicho… - Tumor biology, 2015 - Springer
Human papillomavirus (HPV) infection is necessary but not a sufficient cause for the
development of invasive cervical cancer (ICC). Epithelial tissues, target for HPV, are …

Association between genetic polymorphisms of (Cu/ZnSOD and CAT C262T) and the risk of breast cancer

YH Al-Mawlah, YF Alasadi, MN Al-Darraji - Gene Reports, 2021 - Elsevier
In a number of malignancies, oxidative stress plays a role. SOD is an endogenous
antioxidant enzyme that aids in the reduction of oxidative stress. The goal of this study was …

Predisposition of SOD1, GPX1, CAT genetic variants and their haplotypes in cataractogenesis of type 2 diabetes mellitus in Pakistan

S Kafeel, Z Hashim, A Fawwad, SN Nawab - Acta Diabetologica, 2022 - Springer
Aims Cataract formation is accelerated by hyperglycemia due to the excessive production of
oxidative stress. This study aimed to examine the underlaying role of glutathione peroxidase …