Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

Lynch, MA. Long-Term Potentiation and Memory. Physiol Rev 84: 87–136, 2004;
10.1152/physrev. 00014.2003.—One of the most significant challenges in neuroscience is to …

The contribution of glutamate to synaptic transmission, plasticity and development is well
established; current evidence is based on diverse approaches to decipher function and …

Duchenne muscular dystrophy (DMD) is caused by frameshift mutations in the DMD gene
that prevent the body-wide translation of its protein product, dystrophin. Besides a severe …

Advances in cognitive neuroscience and neuropharmacology are yielding exciting
treatments for neurologic diseases. Many of these treatments are also likely to have uses for …

Brain-derived neurotrophic factor (BDNF) stimulates local dendritic mRNA translation and is
involved in formation and consolidation of memory. 2 H, 3 H, 6 aH-pyrrolidino [2 ″, 1 ″-3 …

Long-term potentiation (LTP) in the hippocampus and long-term depression (LTD) in the
cerebellum are two forms of long-lasting synaptic plasticity that currently serve as our …

Glutamate α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid (AMPA) receptors
mediate most of the excitatory neurotransmission in the mammalian central nervous system …

Cognitive impairment is a core feature of schizophrenia as deficits are present in the majority
of patients, frequently precede the onset of other positive symptoms, persist even with …

A centrally active drug that enhances AMPA receptor-mediated currents was tested for its
effects on memory in humans. Evidence for a positive influence on encoding was obtained …