Stem cells have essential functions in the development and maintenance of our organs.
Improper regulation of adult stem cells and tissue homeostasis can result in cancers and …

The age-associated decline of regenerative capacity in many tissues is a consequence of
stem cell intrinsic and extrinsic perturbations that are only beginning to be understood. To …

Chromodomain helicase DNA-binding protein 7 (CHD7), an ATP-dependent eukaryotic
chromatin remodeling enzyme, is essential for the development of organs. The mutation of …

Sleep disturbances in autism and neurodevelopmental disorders are common and
adversely affect patient's quality of life, yet the underlying mechanisms are understudied. We …

CHD7 encodes an ATP-dependent chromatin remodeling factor. Mutation of this gene
causes multiple developmental disorders, including CHARGE (Coloboma of the eye, Heart …

Tissue homeostasis requires long-term lineage fidelity of somatic stem cells. Whether and
how age-related changes in somatic stem cells impact the faithful execution of lineage …

Transposable elements (TEs) play a significant role in evolution, contributing to genetic
variation. However, TE mobilization in somatic cells is not well understood. Here, we …

The extensive involvement of lysine methyltransferase 2C (KMT2C) in the inflammatory
response is well-documented. However, little is known about the role of KMT2C in psoriasis …

Aims Haploinsufficiency of the chromo-domain protein CHD7 underlies most cases of
CHARGE syndrome, a multisystem birth defect including congenital heart malformation …

Tissue homeostasis relies on rewiring of stem cell transcriptional programs into those of
differentiated cells. Here, we investigate changes in chromatin occurring in a bipotent adult …