The development of multitarget-directed ligands (MTDLs) has become a widely focused
research topic, but rational design remains as an enormous challenge. This paper reviews …

The presented review is an attempt to summarize a huge volume of data on 5-ene-4-
thiazolidinones being a widely studied class of small molecules used in modern organic and …

Abstract Properties of responsible for biological activity tetrazoles are considered. Examples
are given of active pharmaceutical ingredients of modern drugs containing the tetrazole ring …

Rhodanines are accepted as advantaged heterocycles in medicinal chemistry as one of the
4-thiazolidinones subtypes. The aim of this paper is to analyze the features of rhodanine and …

Rhodanines, thiazolidine-2, 4-diones and pseudothiohydantoins have become a very
interesting class of heterocyclic compounds since the introduction of various glitazones and …

Introduction: Rhodanines, as one of the 4-thiazolidinones subtypes, are recognized as
privileged heterocycles in medicinal chemistry. The main achievements include the …

Background: Design of small molecules which are able to bind to the protein responsible for
a disease is the key step of the entire process of the new medicine discovery. Atomistic …

Using a training set of diketo-like acid HIV-1 integrase (IN) strand-transfer inhibitors, a 3D
pharmacophore model was derived having quantitative predictive ability in terms of activity …

Influenza virus (IFV) causes periodic global influenza pandemics, resulting in substantial
socioeconomic loss and burden on medical facilities. Yearly variation in the effectiveness of …

Success stories of computer‐aided design Page 395 377 16 SUCCESS STORIES OF
COMPUTER-AIDED DESIGN Hugo Kubinyi Contents 16.1 Introduction 16.2 Receptors 16.2. 1 G …