Significance: Blood–brain barrier (BBB) disruption is a major pathological change after
intracerebral hemorrhage (ICH) and is both the cause and result of oxidative stress and of …

Intracerebral hemorrhage (ICH) accounts for about 10% of all strokes in the United States of
America causing a high degree of disability and mortality. There is initial (primary) brain …

Immunotherapy has had a tremendous impact on cancer treatment in the past decade, with
hitherto unseen responses at advanced and metastatic stages of the disease. However, the …

Multiple sclerosis (MS) is a T cell-mediated autoimmune disease of the central nervous
system (CNS). Bone marrow hematopoietic stem and progenitor cells (HSPCs) rapidly …

Hemorrhagic stroke is the deadliest form of stroke and includes the subtypes of intracerebral
hemorrhage and subarachnoid hemorrhage. A common cause of hemorrhagic stroke in …

Background Inflammation contributes to the poor prognosis of intracerebral hemorrhage
(ICH). Intermittent fasting (IF) has been shown to be protective against inflammation in …

Although traumatic brain injury (TBI) is a common cause of death and disability worldwide,
there is currently a lack of effective therapeutic drugs and targets. To reveal the complex …

Aged microglia display augmented inflammatory activity after neural injury. Although aging
is a risk factor for poor outcome after brain insults, the precise impact of aging-related …

Stroke is a sudden and rapidly progressing ischemic or hemorrhagic cerebrovascular
disease. When stroke damages the brain, the immune system becomes hyperactive, leading …

Leukocyte infiltration accelerates brain injury following intracerebral hemorrhage (ICH). Yet,
the involvement of T lymphocytes in this process has not been fully elucidated. Here, we …