Transition metal-catalysed carbene-and nitrene transfer to the C1-building blocks carbon
monoxide and isocyanides provides heteroallenes (ie ketenes, isocyanates, ketenimines …

Cancer is one of the leading causes of death. Globally a huge number of deaths and new
incidences are reported annually. Heterocyclic compounds have been proved to be very …

Isocyanides have long been known as versatile chemical reagents in organic synthesis.
Their ambivalent nature also allows them to function as a CO-substitute in palladium …

A silver-catalyzed cascade cyclization reaction of isocyanides with sulfoxonium ylides has
been developed for the first time. This reaction provides a new and efficient method for the …

Xanthine oxidase (XO) has been primarily targeted for the development of anti-
hyperuriciemic/anti-gout agents as it catalyzes the conversion of xanthine and hypoxanthine …

This review covers article and patent data obtained mostly within the period 2013− 2023 on
the synthesis and biological activity of quinazolines [c]-annelated by five-and six-membered …

Transition‐metal‐catalyzed cross‐coupling reaction of azides with isocyanides, as a new
type of nitrene transformation, has become an expeditious method to prepare carbodiimides …

A series of 30 non-covalent imidazo [1, 2-a] quinoxaline-based inhibitors of epidermal
growth factor receptor (EGFR) were designed and synthesized. EGFR inhibitory assessment …

In the quest to ameliorate the camptothecin (CPT) downsides, we expedite to search for
stable non-CPT analogues among 11 motifs of pyrazoloquinazolines reported. E …

Imidazole-based epidermal growth factor receptor (EGFR) inhibitors were computationally
designed and synthesized. All the compounds were assessed for their anti-proliferative …