[HTML][HTML] Emerging concepts in the science of vaccine adjuvants
B Pulendran, P S. Arunachalam… - Nature Reviews Drug …, 2021 - nature.com
Adjuvants are vaccine components that enhance the magnitude, breadth and durability of
the immune response. Following its introduction in the 1920s, alum remained the only …
the immune response. Following its introduction in the 1920s, alum remained the only …
[HTML][HTML] Human immune diversity: from evolution to modernity
The extreme diversity of the human immune system, forged and maintained throughout
evolutionary history, provides a potent defense against opportunistic pathogens. At the same …
evolutionary history, provides a potent defense against opportunistic pathogens. At the same …
[HTML][HTML] New-onset IgG autoantibodies in hospitalized patients with COVID-19
SE Chang, A Feng, W Meng, SA Apostolidis… - Nature …, 2021 - nature.com
COVID-19 is associated with a wide range of clinical manifestations, including autoimmune
features and autoantibody production. Here we develop three protein arrays to measure IgG …
features and autoantibody production. Here we develop three protein arrays to measure IgG …
An inflammatory aging clock (iAge) based on deep learning tracks multimorbidity, immunosenescence, frailty and cardiovascular aging
While many diseases of aging have been linked to the immunological system, immune
metrics capable of identifying the most at-risk individuals are lacking. From the blood …
metrics capable of identifying the most at-risk individuals are lacking. From the blood …
[HTML][HTML] Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination
Several studies have shown that the pre-vaccination immune state is associated with the
antibody response to vaccination. However, the generalizability and mechanisms that …
antibody response to vaccination. However, the generalizability and mechanisms that …
A clinically meaningful metric of immune age derived from high-dimensional longitudinal monitoring
Immune responses generally decline with age. However, the dynamics of this process at the
individual level have not been characterized, hindering quantification of an individual's …
individual level have not been characterized, hindering quantification of an individual's …
[HTML][HTML] Vaccination in the elderly: the challenge of immune changes with aging
The unprecedented increase of life expectancy challenges society to protect the elderly from
morbidity and mortality making vaccination a crucial mean to safeguard this population …
morbidity and mortality making vaccination a crucial mean to safeguard this population …
Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states
Low-grade, chronic inflammation has been associated with many diseases of aging, but the
mechanisms responsible for producing this inflammation remain unclear. Inflammasomes …
mechanisms responsible for producing this inflammation remain unclear. Inflammasomes …
Age-dependent dysregulation of innate immunity
As we age, the innate immune system becomes dysregulated and is characterized by
persistent inflammatory responses that involve multiple immune and non-immune cell types …
persistent inflammatory responses that involve multiple immune and non-immune cell types …