[HTML][HTML] Targeting NF-κB pathway for the therapy of diseases: mechanism and clinical study
H Yu, L Lin, Z Zhang, H Zhang, H Hu - Signal transduction and targeted …, 2020 - nature.com
NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …
activated by various stimuli, transducing a quick but transient transcriptional activity, to …
[HTML][HTML] Recent insights of T cell receptor-mediated signaling pathways for T cell activation and development
JR Hwang, Y Byeon, D Kim, SG Park - Experimental & molecular …, 2020 - nature.com
T cell activation requires extracellular stimulatory signals that are mainly mediated by T cell
receptor (TCR) complexes. The TCR recognizes antigens on major histocompatibility …
receptor (TCR) complexes. The TCR recognizes antigens on major histocompatibility …
[HTML][HTML] Molecular mechanisms of treg-mediated T cell suppression
A Schmidt, N Oberle, PH Krammer - Frontiers in immunology, 2012 - frontiersin.org
CD4+ CD25highFoxp3+ regulatory T cells (Tregs) can suppress other immune cells and,
thus, are critical mediators of peripheral self-tolerance. On the one hand, Tregs avert …
thus, are critical mediators of peripheral self-tolerance. On the one hand, Tregs avert …
4-1BB costimulation promotes CAR T cell survival through noncanonical NF-κB signaling
Clinical response to chimeric antigen receptor (CAR) T cell therapy is correlated with CAR T
cell persistence, especially for CAR T cells that target CD19+ hematologic malignancies. 4 …
cell persistence, especially for CAR T cells that target CD19+ hematologic malignancies. 4 …
NF-κB, the first quarter-century: remarkable progress and outstanding questions
The ability to sense and adjust to the environment is crucial to life. For multicellular
organisms, the ability to respond to external changes is essential not only for survival but …
organisms, the ability to respond to external changes is essential not only for survival but …
Regulation and function of NF-κB transcription factors in the immune system
S Vallabhapurapu, M Karin - Annual review of immunology, 2009 - annualreviews.org
The mammalian Rel/NF-κB family of transcription factors, including RelA, c-Rel, RelB, NF-
κB1 (p50 and its precursor p105), and NF-κB2 (p52 and its precursor p100), plays a central …
κB1 (p50 and its precursor p105), and NF-κB2 (p52 and its precursor p100), plays a central …
NF-κB regulation in the immune system
The nuclear factor-κB (NF-κB)/REL family of transcription factors has a central role in
coordinating the expression of a wide variety of genes that control immune responses. There …
coordinating the expression of a wide variety of genes that control immune responses. There …
Signaling to NF-κB
The transcription factor NF-κB has been the focus of intense investigation for nearly two
decades. Over this period, considerable progress has been made in determining the …
decades. Over this period, considerable progress has been made in determining the …
CD28 and CTLA‐4 coreceptor expression and signal transduction
CE Rudd, A Taylor, H Schneider - Immunological reviews, 2009 - Wiley Online Library
T‐cell activation is mediated by antigen‐specific signals from the TCRζ/CD3 and CD4–CD8–
p56lck complexes in combination with additional co‐signals provided by coreceptors such …
p56lck complexes in combination with additional co‐signals provided by coreceptors such …
[HTML][HTML] Missing pieces in the NF-κB puzzle
The regulation of the transcription factor NF-κB activity occurs at several levels including
controlled cytoplasmic-nuclear shuttling and modulation of its transcriptional activity. A …
controlled cytoplasmic-nuclear shuttling and modulation of its transcriptional activity. A …