Immunotherapies for hepatocellular carcinoma

JM Llovet, F Castet, M Heikenwalder… - Nature reviews Clinical …, 2022 - nature.com
Liver cancer, more specifically hepatocellular carcinoma (HCC), is the second leading
cause of cancer-related death and its incidence is increasing globally. Around 50% of …

The liver cancer immune microenvironment: Therapeutic implications for hepatocellular carcinoma

R Donne, A Lujambio - Hepatology, 2023 - journals.lww.com
The liver is the sixth most common site of primary cancer in humans and the fourth leading
cause of cancer‐related death in the world. Hepatocellular carcinoma (HCC) accounts for …

AlphaFold accelerates artificial intelligence powered drug discovery: efficient discovery of a novel CDK20 small molecule inhibitor

F Ren, X Ding, M Zheng, M Korzinkin, X Cai, W Zhu… - Chemical …, 2023 - pubs.rsc.org
The application of artificial intelligence (AI) has been considered a revolutionary change in
drug discovery and development. In 2020, the AlphaFold computer program predicted …

Neutrophils as potential therapeutic targets in hepatocellular carcinoma

D Geh, J Leslie, R Rumney, HL Reeves… - Nature Reviews …, 2022 - nature.com
The success of atezolizumab plus bevacizumab treatment contributed to a shift in systemic
therapies for hepatocellular carcinoma (HCC) towards combinations that include cancer …

The new era of cancer immunotherapy: targeting myeloid-derived suppressor cells to overcome immune evasion

P De Cicco, G Ercolano, A Ianaro - Frontiers in immunology, 2020 - frontiersin.org
Suppression of antitumor immune responses is one of the main mechanisms by which tumor
cells escape from destruction by the immune system. Myeloid-derived suppressor cells …

From bench to bed: the tumor immune microenvironment and current immunotherapeutic strategies for hepatocellular carcinoma

Y Fu, S Liu, S Zeng, H Shen - Journal of Experimental & Clinical Cancer …, 2019 - Springer
Hepatocellular carcinoma (HCC) ranks the most common primary liver malignancy and the
third leading cause of tumor-related mortality worldwide. Unfortunately, despite advances in …

Current perspectives on the immunosuppressive tumor microenvironment in hepatocellular carcinoma: challenges and opportunities

C Lu, D Rong, B Zhang, W Zheng, X Wang, Z Chen… - Molecular cancer, 2019 - Springer
Incidence of hepatocellular carcinoma (HCC) is on the rise due to the prevalence of chronic
hepatitis and cirrhosis. Although there are surgical and chemotherapy treatment avenues …

Myeloid-derived suppressor cells hinder the anti-cancer activity of immune checkpoint inhibitors

R Weber, V Fleming, X Hu, V Nagibin, C Groth… - Frontiers in …, 2018 - frontiersin.org
Immune checkpoint inhibitors (ICI) used for cancer immunotherapy were shown to boost the
existing anti-tumor immune response by preventing the inhibition of T cells by tumor cells …

Strategies to improve the antitumor effect of immunotherapy for hepatocellular carcinoma

R Xing, J Gao, Q Cui, Q Wang - Frontiers in immunology, 2021 - frontiersin.org
Hepatocellular carcinoma (HCC), one of the most fatal malignancies in the world, is usually
diagnosed in advanced stages due to late symptom manifestation with very limited …

Tumor immune microenvironment and immunosuppressive therapy in hepatocellular carcinoma: a review

K Oura, A Morishita, J Tani, T Masaki - International journal of molecular …, 2021 - mdpi.com
Liver cancer has the fourth highest mortality rate of all cancers worldwide, with
hepatocellular carcinoma (HCC) being the most prevalent subtype. Despite great advances …