Nrf2 is a major transcription factor that significantly regulates—directly or indirectly—more
than 2000 genes. While many of these genes are involved in maintaining redox balance …

Mitochondria are key structures providing most of the energy needed to maintain
homeostasis. They are the main source of adenosine triphosphate (ATP), participate in …

The development of high‐resolution respirometry (HRR) has greatly expanded the analytical
scope to study mitochondrial respiratory control relative to specific tissue/cell types across …

Men are diagnosed with type 2 diabetes at lower body mass indexes than women; the role
of skeletal muscle in this sex difference is poorly understood. Type 2 diabetes impacts …

Nuclear factor-erythroid 2-related factor-2 (Nrf2) is a transcription factor that serves as a
master regulator of anti-inflammatory agents, phase I xenobiotic, and phase II antioxidant …

Aim Alzheimer's disease (AD) is the most common form of dementia. However, while 150+
animal models of AD exist, drug translation from preclinical models to humans for treatment …

Abstract Circulating BDNF (serum-, platelet-and plasma-derived) and cerebral blood flow
(duplex ultrasound) was quantified in 12 healthy human participants (6 male, 6 female) …

Background: Several tissues contribute to the onset and advancement of knee osteoarthritis
(OA). One tissue type that is worthy of closer evaluation, particularly in the context of sex, is …

Because the soleus has a significantly larger percentage of type I fibres than the
gastrocnemius, the soleus may be more resilient to an age-related loss in skeletal muscle …

Protein oxidation is defined as the covalent modification of a protein induced either directly
by reactive oxygen species or indirectly by reaction with secondary by-products of oxidative …