The Apicomplexan AP2 family: integral factors regulating Plasmodium development
HJ Painter, TL Campbell, M Llinás - Molecular and biochemical …, 2011 - Elsevier
Malaria is caused by protozoan parasites of the genus Plasmodium and involves infection of
multiple hosts and cell types during the course of an infection. To complete its complex life …
multiple hosts and cell types during the course of an infection. To complete its complex life …
The dynamic roles of the inner membrane complex in the multiple stages of the malaria parasite
Apicomplexan parasites, such as human malaria parasites, have complex lifecycles
encompassing multiple and diverse environmental niches. Invading, replicating, and …
encompassing multiple and diverse environmental niches. Invading, replicating, and …
Single-cell RNA-seq reveals hidden transcriptional variation in malaria parasites
Single-cell RNA-sequencing is revolutionising our understanding of seemingly
homogeneous cell populations but has not yet been widely applied to single-celled …
homogeneous cell populations but has not yet been widely applied to single-celled …
Atlas of Plasmodium falciparum intraerythrocytic development using expansion microscopy
Apicomplexan parasites exhibit tremendous diversity in much of their fundamental cell
biology, but study of these organisms using light microscopy is often hindered by their small …
biology, but study of these organisms using light microscopy is often hindered by their small …
Chromerid genomes reveal the evolutionary path from photosynthetic algae to obligate intracellular parasites
The eukaryotic phylum Apicomplexa encompasses thousands of obligate intracellular
parasites of humans and animals with immense socio-economic and health impacts. We …
parasites of humans and animals with immense socio-economic and health impacts. We …
Identification and genome-wide prediction of DNA binding specificities for the ApiAP2 family of regulators from the malaria parasite
TL Campbell, EK De Silva, KL Olszewski… - PLoS …, 2010 - journals.plos.org
The molecular mechanisms underlying transcriptional regulation in apicomplexan parasites
remain poorly understood. Recently, the Apicomplexan AP2 (ApiAP2) family of DNA binding …
remain poorly understood. Recently, the Apicomplexan AP2 (ApiAP2) family of DNA binding …
Transcriptional variation in the malaria parasite Plasmodium falciparum
N Rovira-Graells, AP Gupta, E Planet… - Genome …, 2012 - genome.cshlp.org
Malaria genetic variation has been extensively characterized, but the level of epigenetic
plasticity remains largely unexplored. Here we provide a comprehensive characterization of …
plasticity remains largely unexplored. Here we provide a comprehensive characterization of …
Cellular thermal shift assay for the identification of drug–target interactions in the Plasmodium falciparum proteome
Despite decades of research, little is known about the cellular targets and the mode of action
of the vast majority of antimalarial drugs. We recently demonstrated that the cellular thermal …
of the vast majority of antimalarial drugs. We recently demonstrated that the cellular thermal …
Red blood cell invasion by the malaria parasite is coordinated by the PfAP2-I transcription factor
Obligate intracellular parasites must efficiently invade host cells in order to mature and be
transmitted. For the malaria parasite Plasmodium falciparum, invasion of host red blood cells …
transmitted. For the malaria parasite Plasmodium falciparum, invasion of host red blood cells …
Multistage and transmission-blocking targeted antimalarials discovered from the open-source MMV Pandemic Response Box
J Reader, ME van der Watt, D Taylor… - Nature …, 2021 - nature.com
Chemical matter is needed to target the divergent biology associated with the different life
cycle stages of Plasmodium. Here, we report the parallel de novo screening of the …
cycle stages of Plasmodium. Here, we report the parallel de novo screening of the …