Abstract c-Met is a prototype member of a subfamily of heterodimeric receptor tyrosine
kinases (RTKs) and is the receptor for hepatocyte growth factor (HGF). Binding of HGF to its …

Background: The Mediterranean diet is linked to various health benefits, especially the
consumption of olive oil as a key component. Multiple studies highlight its advantages …

Oleocanthal is a minor constituent of olive oil with strong anti-inflammatory activities. Since
the pathogenesis of many chronic diseases involves inflammatory and oxidative …

Receptor tyrosine kinases (RTKs) are pharmaceutically attractive targets due to their
fundamental role in tumor formation. The hallmark of pancreatic cancer is its high mortality …

Luminal breast cancer represents a therapeutic challenge in terms of aggressive disease
and emerging resistance to targeted therapy.(-)-Oleocanthal has demonstrated anticancer …

Wild chervil (Anthriscus sylvestris) is a widespread, wild-growing herbaceous plant from
Apiaceae family, known for high content of lignans related to podophyllotoxin, and thus …

Frequent oncogenic mutations have been identified in MAPK (mitogen-activated protein
kinase) signaling pathway components. As a result, MAPK pathway is associated with …

A series of cinnamic acid derivatives, amides (1–12) and esters (13–22), were synthesized,
and structure–activity relationships for antioxidant activity, and monoamine oxidases (MAO) …

Abstract c-Met receptor tyrosine kinase is a proto-oncogene whose aberrant activation is
attributed to a lower rate of survival in most cancers. Natural product-derived inhibitors …

A potent and novel MET inhibitor, 5-((4-((2-amino-3-chloropyridin-4-yl) oxy)-3-fluorophenyl)
amino)-3-(4-fluorophenyl)-1, 6-naphthyridin-4 (1H)-ones (8), was designed and synthesized …