All organisms suffer double‐strand breaks (DSBs) in their DNA as a result of exposure to
ionizing radiation. DSBs can also form when replication forks encounter DNA lesions or …

Double-strand breaks (DSBs), continuously introduced into DNA by cell metabolism,
ionizing radiation and some chemicals, are the biologically most deleterious type of genome …

In the nucleus of animal and plant cells individual chromosomes maintain a
compartmentalized structure. Chromosome territories (CTs), as these structures were named …

DNA is under constant assault from genotoxic agents which creates different kinds of DNA
damage. The precise replication of the genome and the continuous surveillance of its …

Genomic DNA in eukaryotic cells is basically divided into chromosomes, each consisting of
a single huge nucleosomal fiber. It is now clear that chromatin structure and dynamics play a …

The faithful repair of DNA double-strand breaks (DSBs) is probably one of the most critical
tasks for a cell in order to maintain its genomic integrity since these lesions may lead to …

Telomeres, the ends of linear chromosomes, play a major role in the maintenance of
genome integrity. Telomerase or alternative lengthening of telomeres (ALT) mechanisms …

The invasiveness of breast cancer cells was shown to be associated with the suppressed
ability to develop apoptosis. The role of cell death DNases/endonucleases has not been …

DNA double strand breaks (DSBs) are ultimate lesions for the formation of chromosomal
aberrations (CAs). The formation of CAs is dependent on many factors; some of these are …

Peripheral lymphocytes were exposed to 4 Gy X-rays and aberrations were analysed in
human chromosome 5 using high-resolution multicolour banding fluorescence in-situ …