Cytotoxic CD8+ T cells play a key role in the elimination of intracellular infections and
malignant cells and can provide long-term protective immunity. In the response to infection …

Tumors display reprogrammed metabolic activities that promote cancer progression. We
currently possess a limited understanding of the processes governing tumor metabolism in …

We present a new update to MetaboAnalyst (version 4.0) for comprehensive metabolomic
data analysis, interpretation, and integration with other omics data. Since the last major …

Endothelial cells (ECs) are more than inert blood vessel lining material. Instead, they are
active players in the formation of new blood vessels (angiogenesis) both in health and (life …

Cancer cells reprogramme their metabolism to support unrestrained proliferation and
survival in nutrient-poor conditions. Whereas non-transformed cells often have lower …

Major depressive disorder (MDD) is a serious mental illness, characterized by high
morbidity, which has increased in recent decades. However, the molecular mechanisms …

Cancer cells without mitochondrial DNA (mtDNA) do not form tumors unless they
reconstitute oxidative phosphorylation (OXPHOS) by mitochondria acquired from host …

Cancer exerts a multitude of effects on metabolism, including the reprogramming of cellular
metabolic pathways and alterations in metabolites that facilitate inappropriate proliferation of …

The extracellular milieu of tumors is generally assumed to be immunosuppressive due in
part to metabolic factors. Here, we review methods for probing the tumor metabolic …

Colorectal carcinoma (CRC) is one of the most frequently diagnosed carcinomas and one of
the leading causes of cancer-related death worldwide. Metabolic reprogramming, a hallmark …