The advent of heme during evolution allowed organisms possessing this compound to
safely and efficiently carry out a variety of chemical reactions that otherwise were difficult or …

Synthetic pyrrole-based anion receptors date back to the 1990s. They have been
extensively developed in the context of macrocyclic systems such as expanded porphyrins …

The three-domain structure of porphobilinogen deaminase, a key enzyme in the biosynthetic
pathway of tetrapyrroles, has been defined by X-ray analysis at 1.9 Å resolution. Two of the …

Patients with major forms of acute hepatic porphyria present acute neurological attacks with
overproduction of porphobilinogen (PBG) and δ-aminolevulinic acid (ALA). Even if ALA is …

Porphobilinogen deaminase (PBGD) catalyses the polymerization of four molecules of
porphobilinogen to form the 1‐hydroxymethylbilane, preuroporphyrinogen, a key …

Abstract Porphobilinogen deaminase (EC 4.3. 1.8) has been purified to homogeneity
(16,000-fold) from the plant Arabidopsis thaliana in yields of 8%. The deaminase is a …

The enzyme hydroxymethylbilane synthase (HMBS, EC 4.3. 1.8) catalyzes the conversion of
porphobilinogen into hydroxymethylbilane, a key intermediate for the biosynthesis of heme …

Anion sensing plays a crucial role in areas ranging from medical diagnostics to
environmental monitoring. Dipyrromethane‐based compounds offer a versatile platform for …

Hydroxymethylbilane synthase (HMBS) catalyses the conversion of porphobilinogen into
hydroxymethylbilane, a linear tetrapyrrolic intermediate in the biosynthesis of haems …

Porphobilinogen deaminase (PBG-D), an early enzyme of the tetrapyrrole biosynthetic
pathway, catalyzes the formation of a tetrapyrrole chain, preuroporphyrinogen, from four …